860521 | C16 Galactosyl(ß) Ceramide (d18:1/16:0)
D-galactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine
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C16 Galactosyl(ß) Ceramide (d18:1/16:0)
D-galactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine
C16 galactosyl(ß) ceramide (d18:1/16:0), also known as D-galactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine, is a complex glycosphingolipid composed of a sphingosine backbone (d18:1) linked to a palmitoyl fatty acid (16:0) and a galactosyl sugar moiety. With a molecular formula of C40H77NO8, this molecule is a key component of cell membranes, particularly in the nervous system, where it plays a crucial role in the formation and maintenance of myelin sheaths.
Application
Galactosylceramides are key components of myelin in the nervous system, where they insulate nerve fibers and support rapid signal transmission. Widely used in neurobiology research, C16 galactosyl(ß) ceramide helps study myelin structure and function, including cell signaling pathways involved in neurodegeneration.
It is also significant for exploring disease pathogenesis in demyelinating disorders like multiple sclerosis, helping with the development of potential therapeutic approaches. By analyzing its role in myelin stability, researchers can use this compound to find insights into the mechanisms underlying nerve function and neurodegenerative diseases.
Packaging
Avanti Research™ provides GalCer (d18:1/16:0) C16 ß-D-galactosyl ceramide N-(hexadecanoyl)-1-ß-galactosyl-sphing-4-enine in powder form in 5 mg packaging.
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CAS Registry Number is a Registered Trademark of the American Chemical Society
C16 ß-D-galactosyl ceramide
N-(hexadecanoyl)-1-ß-galactosyl-sphing-4-enine
Powered by BiozLelieveld LT, Mirzaian M, Kuo CL, Artola M, Ferraz MJ, Peter REA, Akiyama H, Greimel P, van den Berg RJBHN, Overkleeft HS, Boot RG, Meijer AH, Aerts JMFG. Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish. J Lipid Res. 2019 Nov;60(11):1851-1867. doi: 10.1194/jlr.RA119000154. Epub 2019 Sep 27.
von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, Jennemann R, Gröne HJ, Mack M, Sandhoff R. Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals. J Lipid Res. 2017 Jun;58(6):1247-1258. doi: 10.1194/jlr.D076190. Epub 2017 Apr 3.
PubMed ID: 28373486- Certificate of Analysis (Lot No. 860521P-5MG-A-010 and 5973PHA010)
- Certificate of Analysis (Lot No. 860521P-5MG-C-010 and 5973PHC010)
- Certificate of Analysis (Lot No. 860521P-5MG-D-010 and 5973PHD010)
- Certificate of Analysis (Lot No. 860521P-5MG-E-010 and 5973PHE010)
- Certificate of Analysis (Lot No. 860521P-5MG-F-010 and 5973PHF010)
- Certificate of Analysis (Lot No. 860521P-5MG-H-010 and 5973PHH010)
- Certificate of Analysis (Lot No. 860521P-5MG-I-010 and 5973PHI010)
- Certificate of Analysis (Lot No. 860521P-5MG-J-010 and 5973PHJ010)
