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860518 | C18 Ceramide (d18:1/18:0)

N-stearoyl-D-erythro-sphingosine

C18 Ceramide (d18:1/18:0)

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5mg 860518P-5mg 860518P-5mg 1 x 5mg $94.45
10mg 860518P-10mg 860518P-10mg 1 x 10mg $177.70
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Info

C18 Ceramide (d18:1/18:0)

N-stearoyl-D-erythro-sphingosine

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C36H71NO3
Percent Composition
C 76.40%, H 12.64%, N 2.47%, O 8.48%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
2304-81-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
565.954
Exact Mass
565.543
Synonyms
N-(octadecanoyl)-sphing-4-enine
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References

Govindarajan S, Verheugen E, Venken K, Gaublomme D, Maelegheer M, Cloots E, Gysens F, De Geest BG, Cheng TY, Moody DB, Janssens S, Drennan M, Elewaut D. ER stress in antigen-presenting cells promotes NKT cell activation through endogenous neutral lipids. EMBO Rep. 2020 Jun 4;21(6):e48927. doi: 10.15252/embr.201948927. Epub 2020 May 3. PMID: 32363653; PMCID: PMC7271650.

 PubMed ID: 32363653

Li F, Huangyang P, Burrows M, Guo K, Riscal R, Godfrey J, Lee KE, Lin N, Lee P, Blair IA, Keith B, Li B, Simon MC. FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome. Nat Cell Biol. 2020 Jun;22(6):728-739. doi: 10.1038/s41556-020-0511-2. Epub 2020 May 4. PMID: 32367049; PMCID: PMC7286794.

 PubMed ID: 32367049

Aslan M, Afşar E, Kırımlıoglu E, Çeker T, Yılmaz Ç. Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress. Nutr Cancer. 2020 Apr 14:1-13. doi: 10.1080/01635581.2020.1751216. Epub ahead of print. PMID: 32286088.

 PubMed ID: 32286088

Régnier M, Polizzi A, Smati S, Lukowicz C, Fougerat A, Lippi Y, Fouché E, Lasserre F, Naylies C, Bétoulières C, Barquissau V, Mouisel E, Bertrand-Michel J, Batut A, Saati TA, Canlet C, Tremblay-Franco M, Ellero-Simatos S, Langin D, Postic C, Wahli W, Loiseau N, Guillou H, Montagner A. Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity. Sci Rep. 2020 Apr 16;10(1):6489. doi: 10.1038/s41598-020-63579-3. PMID: 32300166; PMCID: PMC7162950.

 PubMed ID: 32300166

Afşar E, Kırımlıoglu E, Çeker T, Yılmaz Ç, Demir N, Aslan M. Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells. Redox Biol. 2020 Feb;30:101430. doi: 10.1016/j.redox.2020.101430. Epub 2020 Jan 20. PMID: 31978676; PMCID: PMC6976939.

 PubMed ID: 31978676

Arshad H, Alfonso JCL, Franke R, Michaelis K, Araujo L, Habib A, Zboromyrska Y, Lücke E, Strungaru E, Akmatov MK, Hatzikirou H, Meyer-Hermann M, Petersmann A, Nauck M, Brönstrup M, Bilitewski U, Abel L, Sievers J, Vila J, Illig T, Schreiber J, Pessler F. Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia. J Transl Med. 2019 Nov 11;17(1):365. doi: 10.1186/s12967-019-2112-z.

 PubMed ID: 31711507

Kao LP, Morad SAF, Davis TS, MacDougall MR, Kassai M, Abdelmageed N, Fox TE, Kester M, Loughran TP Jr, Abad JL, Fabrias G, Tan SF, Feith DJ, Claxton DF, Spiegel S, Fisher-Wellman KH, Cabot MC. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res. 2019 Sep;60(9):1590-1602. doi: 10.1194/jlr.RA119000251. Epub 2019 Jul 30.

 PubMed ID: 31363040

Rivas DA, Rice NP, Ezzyat Y, McDonald DJ, Cooper BE, Fielding RA. Sphingosine-1-phosphate analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction. Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C502-C512. doi: 10.1152/ajpcell.00455.2018. Epub 2019 Jun 26.

 PubMed ID: 31241988

Kaya S, Aslan İ, Kıraç E, Karaarslan T, Aslan M. Serum Sphingolipidomic Analysis in Acne Vulgaris Patients. Ann Clin Lab Sci. 2019 Mar;49(2):242-248.

 PubMed ID: 31028071

Preuss C, Jelenik T, Bódis K, Müssig K, Burkart V, Szendroedi J, Roden M, Markgraf DF. A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver. Cells. 2019 Mar 22;8(3). pii: E277. doi: 10.3390/cells8030277.

 PubMed ID: 30909521

Garić D, De Sanctis JB, Shah J, Dumut DC, Radzioch D. Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain. Prog Lipid Res. 2019 Mar 12;74:130-144. doi: 10.1016/j.plipres.2019.03.001. [Epub ahead of print]

 PubMed ID: 30876862

Leurs CE, Lopes Pinheiro MA, Wierts L, den Hoedt S, Mulder MT, Eijlers AJC, Schoonheim MM, Balk LJ, Uitdehaag BMJ, Killestein J, de Vries HE. Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis. Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30.

 PubMed ID: 30553168

Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):304-311. doi: 10.1016/j.bbalip.2018.12.001. Epub 2018 Dec 15.

 PubMed ID: 30557628

Thomas LL, van der Vegt SA, Fromme JC. A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF. Dev Cell. 2019 Jan 7;48(1):100-114.e9. doi: 10.1016/j.devcel.2018.11.013. Epub 2018 Dec 6.

 PubMed ID: 30528786

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Mueller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, Holthuis JCM. A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. J Lipid Res. 2018 Jan 17. pii: jlr.M082354. doi: 10.1194/jlr.M082354. [Epub ahead of print]

 PubMed ID: 29343537
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