860506 | C6 Ceramide (d18:1/6:0)
N-hexanoyl-D-erythro-sphingosine
C6 Ceramide (d18:1/6:0)
N-hexanoyl-D-erythro-sphingosine
Ceramide forms stable, fluid bilayers with cholesteryl phosphocholine, and this formulation has been shown to be more potent than solvent-delivered (DMSO) formulations of C6 Ceramide in inhibiting proliferation, inducing apoptosis, and disturbing calcium homeostasis.
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozVaquer CC, Suhaiman L, Pavarotti MA, De Blas GA, Belmonte SA. Ceramide induces a multicomponent intracellular calcium increase triggering the acrosome secretion in human sperm. Biochim Biophys Acta Mol Cell Res. 2020 Mar 17:118704. doi: 10.1016/j.bbamcr.2020.118704. Epub ahead of print. PMID: 32194132.
PubMed ID: 32194132Kao LP, Morad SAF, Davis TS, MacDougall MR, Kassai M, Abdelmageed N, Fox TE, Kester M, Loughran TP Jr, Abad JL, Fabrias G, Tan SF, Feith DJ, Claxton DF, Spiegel S, Fisher-Wellman KH, Cabot MC. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res. 2019 Sep;60(9):1590-1602. doi: 10.1194/jlr.RA119000251. Epub 2019 Jul 30.
PubMed ID: 31363040Morad SAF, MacDougall MR, Abdelmageed N, Kao LP, Feith DJ, Tan SF, Kester M, Loughran TP Jr, Wang HG, Cabot MC. Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen. Exp Cell Res. 2019 Aug 15;381(2):256-264. doi: 10.1016/j.yexcr.2019.05.021. Epub 2019 May 18.
PubMed ID: 31112736Yamaguchi D, Imaizumi T, Yagi K, Matsumoto Y, Nakashima T, Hirose A, Kashima N, Nosaka Y, Hamada T, Okawa K, Nishiya Y, Kubo K. Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening. Sci Rep. 2019 May 23;9(1):7742. doi: 10.1038/s41598-019-43994-x.
PubMed ID: 31123329Black AJ, Schilder RJ, Kimball SR. Palmitate- and C6 ceramide-induced Tnnt3 pre-mRNA alternative splicing occurs in a PP2A dependent manner. Nutr Metab (Lond). 2018 Dec 17;15:87. doi: 10.1186/s12986-018-0326-3. eCollection 2018.
PubMed ID: 30564278Suhrland C, Truman JP, Obeid LM, Sitharaman B. Oxidized graphene nanoparticles as a delivery system for the pro-apoptotic sphingolipid C6 ceramide. J Biomed Mater Res A. 2019 Jan;107(1):25-37. doi: 10.1002/jbm.a.36474. Epub 2018 Nov 13.
PubMed ID: 30422374Complexation of C6-Ceramide with Cholesteryl Phosphocholine – A Potent Solvent-Free Ceramide Delivery Formulation for Cells in Culture (2013). Pramod Sukumaran , Max Lönnfors , Otto Långvik, Ilari Pulli, Kid Törnquist, J. Peter Slotte.
PubMed ID: 23620740Flowers, M., G. Fabrias, A. Delgado, J. Casas, J.L. Abad, and M.C. Cabot. (2012). C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth. Breast Cancer Res Treat 133:447-58.
PubMed ID: 21935601- Certificate of Analysis (Lot No. 860506P-10MG-A-015 and 5963PIA015)
- Certificate of Analysis (Lot No. 860506P-5MG-A-015 and 5963PHA015)
- Certificate of Analysis (Lot No. 860506P-10MG-B-015 and 5963PIB015)
- Certificate of Analysis (Lot No. 860506P-5MG-B-015 and 5963PHB015)
- Certificate of Analysis (Lot No. 860506P-5MG-C-015 and 5963PHC015)
- Certificate of Analysis (Lot No. 860506P-10MG-C-015 and 5963PIC015)
- Certificate of Analysis (Lot No. 860506P-5MG-D-015 and 5963PHD015)
- Certificate of Analysis (Lot No. 860506P-10MG-D-015 and 5963PID015)
- Certificate of Analysis (Lot No. 860506P-5MG-E-015 and 5963PHE015)
- Certificate of Analysis (Lot No. 860506P-10MG-E-015 and 5963PIE015)
- Certificate of Analysis (Lot No. 860506P-5MG-F-015 and 5963PHF015)
- Certificate of Analysis (Lot No. 860506P-10MG-A-016 and 5963PIA016)
- Certificate of Analysis (Lot No. 860506P-5MG-A-016 and 5963PHA016)
- Certificate of Analysis (Lot No. 860506P-5MG-D-016 and 5963PHD016)
- Certificate of Analysis (Lot No. 860506P-10MG-B-016 and 5963PIB016)
- Certificate of Analysis (Lot No. 860506P-10MG-C-016 and 5963PIC016)
