860490 | Sphingosine (d18:1)
D-erythro-sphingosine

Please Confirm Your Location
Effective March 1, 2018, Merck KGaA, Darmstadt, Germany* is the exclusive Distributor of Avanti Research. Research Products for all countries except the United States. For product pricing and order placement, please click on the appropriate Location Box below.
For customers located outside the United States, you will be redirected to www.sigmaaldrich.com/avanti prior to completing your purchase. Thank you for your continued business and support of Avanti Research!
*The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada
Sphingosine (d18:1)
D-erythro-sphingosine
CAS Registry Number is a Registered Trademark of the American Chemical Society
2S, 3R(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol
(2S,3R,4E)-2-amino-1,3-octadec-4-enediolsphing-4-enine
110750
Jakobi K, Beyer S, Koch A, Thomas D, Schwalm S, Zeuzem S, Pfeilschifter J, Grammatikos G. Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro. Int J Mol Sci. 2020 Mar 31;21(7):2409. doi: 10.3390/ijms21072409. PMID: 32244391; PMCID: PMC7177910.
PubMed ID: 32244391Santos TCB, Vaz A, Ventura AE, M Saied E, Arenz C, Fedorov A, Prieto M, Silva LC. Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties. Langmuir. 2020 May 15. doi: 10.1021/acs.langmuir.0c01000. Epub ahead of print. PMID: 32369370.
PubMed ID: 32369370Toncic RJ, Jakasa I, Hadzavdic SL, Goorden SM, Vlugt KJG, Stet FS, Balic A, Petkovic M, Pavicic B, Zuzul K, Marinovic B, Kezic S. Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu. Int J Mol Sci. 2020 Mar 13;21(6):1958. doi: 10.3390/ijms21061958. PMID: 32183011; PMCID: PMC7139865.
PubMed ID: 32183011Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8. PMID: 32165633; PMCID: PMC7067866.
PubMed ID: 32165633Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P2 -dependent signaling. FASEB J. 2020 Jan 15:10.1096/fj.201902391R. doi: 10.1096/fj.201902391R. Epub ahead of print. PMID: 31944406.
PubMed ID: 31944406Shao Z, Zhao Y, Liu L, Chen S, Li C, Meng F, Liu H, Hu S, Wang J, Wang Q. Overexpression of FBR41 enhances resistance to sphinganine analog mycotoxin-induced cell death and Alternaria stem canker in tomato. Plant Biotechnol J. 2019 Jun 3. doi: 10.1111/pbi.13182. [Epub ahead of print]
PubMed ID: 31161714Bilog AD, Smulders L, Oliverio R, Labanieh C, Zapanta J, Stahelin RV, Nikolaidis N. Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine. Biomolecules. 2019 Apr 17;9(4). pii: E152. doi: 10.3390/biom9040152.
PubMed ID: 30999671Tomonaga N, Tsuduki T, Manabe Y, Sugawara T. Sphingoid bases of dietary ceramide 2-aminoethylphosphonate, a marine sphingolipid, absorb into lymph in rats. J Lipid Res. 2019 Feb;60(2):333-340. doi: 10.1194/jlr.M085654. Epub 2018 Dec 14.
PubMed ID: 30552287Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):304-311. doi: 10.1016/j.bbalip.2018.12.001. Epub 2018 Dec 15.
PubMed ID: 30557628- Certificate of Analysis (Lot No. 860490P-10MG-A-017 and 5950PIA017)
- Certificate of Analysis (Lot No. 860490P-25MG-A-017 and 5950PJA017)
- Certificate of Analysis (Lot No. 860490P-500MG-A-017 and 5950PPA017)
- Certificate of Analysis (Lot No. 860490P-25MG-A-020 and 5950PJA020)
- Certificate of Analysis (Lot No. 860490P-500MG-A-020 and 5950PPA020)
- Certificate of Analysis (Lot No. 860490P-10MG-A-020 and 5950PIA020)
- Certificate of Analysis (Lot No. 860490P-10MG-B-020 and 5950PIB020)
- Certificate of Analysis (Lot No. 860490P-25MG-B-020 and 5950PJB020)
- Certificate of Analysis (Lot No. 860490P-10MG-C-020 and 5950PIC020)
- Certificate of Analysis (Lot No. 860490P-25MG-C-020 and 5950PJC020)
- Certificate of Analysis (Lot No. 860490P-10MG-D-020 and 5950PID020)
- Certificate of Analysis (Lot No. 860490P-25MG-D-020 and 5950PJD020)
- Certificate of Analysis (Lot No. 860490P-25MG-E-020 and 5950PJE020)
- Certificate of Analysis (Lot No. 860490P-10MG-E-020 and 5950PIE020)
- Certificate of Analysis (Lot No. 860490P-10MG-F-020 and 5950PIF020)
- Certificate of Analysis (Lot No. 860490P-10MG-G-020 and 5950PIG020)
- Certificate of Analysis (Lot No. 860490P-25MG-G-020 and 5950PJG020)
- Certificate of Analysis (Lot No. 860490P-10MG-J-020 and 5950PIJ020)
- Certificate of Analysis (Lot No. 860490P-25MG-H-020 and 5950PJH020)
- Certificate of Analysis (Lot No. 860490P-10MG-K-020 and 5950PIK020)
- Certificate of Analysis (Lot No. 860490P-10MG-L-020 and 5950PIL020)
- Certificate of Analysis (Lot No. 860490P-10MG-M-020 and 5950PIM020)
- Certificate of Analysis (Lot No. 860490P-25MG-I-020 and 5950PJI020)
- Certificate of Analysis (Lot No. 860490P-25MG-J-020 and 5950PJJ020)
- Certificate of Analysis (Lot No. 860490P-10MG-N-020 and 5950PIN020)
- Certificate of Analysis (Lot No. 860490P-10MG-O-020 and 5950PIO020)
- Certificate of Analysis (Lot No. 860490P-10MG-O-020 and 5950PIO020)
- Certificate of Analysis (Lot No. 860490P-25MG-K-020 and 5950PJK020)