Section Menu

860478 | cis-4-methylsphingosine

cis-4-methylsphingosine

cis-4-methylsphingosine

Powder

Size SKU Packaging Price
5mg 860478P-5mg 860478P-5mg 1 x 5mg $149.50
Request Bulk Pricing
Info

cis-4-methylsphingosine

cis-4-methylsphingosine

cis-4-methylsphingosine (cis-4M-Sph) is a synthetic sphingosine analogue that is readily taken up by cells and interacts with S1P receptors through its metabolite cis-4M-S1P in a manner similar to FTY720. cis-4M-Sph interacts primarily with the S1P receptors S1P(2) and S1P(3), and only weakly with S1P(1). cis-4M-Sph induces apoptosis of neuroblastoma cells.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C19H39NO2
Percent Composition
C 72.79%, H 12.54%, N 4.47%, O 10.21%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1407154-31-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
313.518
Exact Mass
313.298
Synonyms
cis-4M-Sph
Downloads
References

Ter Braak M, Claas RF, Hegen B, Labocha S, Ferreirós N, Pfeilschifter J, Huwiler A, van Echten-Deckert G, Meyer Zu Heringdorf D. Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. Biochem Pharmacol. 2011 Mar 1;81(5):617-25. doi: 10.1016/j.bcp.2010.12.002. Epub 2010 Dec 14. PMID: 21163254.

 PubMed ID: 21163254

van Echten-Deckert G, Zschoche A, Bär T, Schmidt RR, Raths A, Heinemann T, Sandhoff K. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J Biol Chem. 1997 Jun 20;272(25):15825-33. doi: 10.1074/jbc.272.25.15825. PMID: 9188480.

 PubMed ID: 9188480
Certificates of Analysis

Cart

Item Price Qty.
${ item.sku }
Base Price: $${ (item.price - (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150))).toFixed(2) }
Custom Packaging: +${ (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150)).toFixed(2) }
Change Custom Packaging 		${ item.salePriceAsCurrency }
Subtotal: ${ cart.itemSubtotal|money }
${ adjustment.type }: ${ adjustment.name } ${ adjustment.amountAsCurrency }
${ adjustment.name } ${ adjustment.amountAsCurrency }
Order Total: ${ cart.totalPriceAsCurrency }
Have a promo code? Enter it in your cart to apply your discount and enjoy the savings on your purchase! Finalize Cart