860409 | 9-PAHSA-d9
9-[((13,13,14,14,15,15,16,16,16-d9)palmitoyl)hydroxy]-stearic acid

Info
9-PAHSA-d9
9-[((13,13,14,14,15,15,16,16,16-d9)palmitoyl)hydroxy]-stearic acid
PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes.
Avanti has obtained a license from the patent holder to manufacture these products for research use.
Data
No
No
C34H57D9O4
C 74.53%, H 13.79%, O 11.68%
>99%
1 Years
-20°C
CAS Number
1809222-43-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
CAS Registry Number is a Registered Trademark of the American Chemical Society
547.941
547.553
References
Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 Aug 23;55(33):4636-41. doi: 10.1021/acs.biochem.6b00565. Epub 2016 Aug 10. PMID: 27509211; PMCID: PMC5056623.
PubMed ID: 27509211Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035. PMID: 25303528; PMCID: PMC4260972.
PubMed ID: 25303528
Certificates of Analysis
- Certificate of Analysis (Lot No. 860409C-1MG-A-010 and 5917CGA010)
- Certificate of Analysis (Lot No. 860409C-500UG-A-010 and 5917CFA010)