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857506 | a15:0-i15:0 PE

1-(12S-methylmyristoyl)-2-(13-methylmyristoyl)-sn-glycero-3-phosphoethanolamine

a15:0-i15:0 PE

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Size SKU Packaging Price
1mg 857506P-1mg 857506P-1mg 1 x 1mg $135.00
5mg 857506P-5mg 857506P-5mg 1 x 5mg $540.00
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Info

a15:0-i15:0 PE

1-(12S-methylmyristoyl)-2-(13-methylmyristoyl)-sn-glycero-3-phosphoethanolamine

a15:0-i15:0 PE is a branched phospholipid that has a methyl branch on both acyl chains. a15:0-i15:0 PE can be used in a wide range of chemical and immunological applications due to it being linked to the immunomodulatory properties of the gut bacterium Akkermansia muciniphila. This gut bacterium has been associated with favorable results on metabolism and checkpoint blockade in cancer immunotherapy. a15:0-i15:0 PE has some key features that set it apart such as being less potent that other known TLR2 agonists, preferentially inducing specific inflammatory cytokines, and at low doses resets activation thresholds for immune signaling.

Bae, M., Cassilly, C.D., Liu, X. et al. Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature 608, 168–173 (2022). 

https://doi.org/10.1038/s41586-022-04985-7

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C35H70NO8P
Percent Composition
C 63.32%, H 10.63%, N 2.11%, O 19.28%, P 4.67%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2936622-21-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
663.92
Exact Mass
663.48
Downloads
Certificates of Analysis

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