857372 | VU0285655-1

N-{2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decan-8-yl]ethyl}quinoline-3-carboxamide

VU0285655-1

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Info

VU0285655-1

N-{2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decan-8-yl]ethyl}quinoline-3-carboxamide

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C25H27N5O2
Percent Composition
C 69.91%, H 6.34%, N 16.31%, O 7.45%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1158347-73-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
429.514
Exact Mass
429.216
Synonyms
APVVU0285655-1
References

Lingrand M, Lalonde S, Jutras-Carignan A, Bergeron KF, Rassart E, Mounier C. SCD1 activity promotes cell migration via a PLD-mTOR pathway in the MDA-MB-231 triple-negative breast cancer cell line. Breast Cancer. 2020 Jan 29:10.1007/s12282-020-01053-8. doi: 10.1007/s12282-020-01053-8. Epub ahead of print. PMID: 31993937.

PubMed ID: 31993937

Tenconi PE, Bermúdez V, Oresti GM, Giusto NM, Salvador GA, Mateos MV. High glucose-induced phospholipase D activity in retinal pigment epithelium cells: New insights into the molecular mechanisms of diabetic retinopathy. Exp Eye Res. 2019 Jul;184:243-257. doi: 10.1016/j.exer.2019.04.028. Epub 2019 May 3.

PubMed ID: 31059692

Wang Z, Cai M, Tay LWR, Zhang F, Wu P, Huynh A, Cao X, Di Paolo G, Peng J, Milewicz DM, Du G. Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation. FASEB J. 2019 Feb 27:fj201800390RR. doi: 10.1096/fj.201800390RR. [Epub ahead of print]

PubMed ID: 30811216

Lavieri R, Scott SA, Lewis JA, Selvy PE, Armstrong MD, Alex Brown H, Lindsley CW. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. doi: 10.1016/j.bmcl.2009.02.125. Epub 2009 Mar 6.

PubMed ID: 19299128
Certificates of Analysis

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