850543 | 8.9 MAG
1-(8Z-heptadecenoyl)-rac-glycerol
8.9 MAG
1-(8Z-heptadecenoyl)-rac-glycerol
This new Lipid detergent may be used for crystallizing membrane proteins by using lipidic mesophases. This method has variously been referred to as the lipidic cubic phase or in meso method. The method has been shown to be quite versatile in that it has been used to solve X-ray crystallographic structures of prokaryotic and eukaryotic proteins, proteins that are monomeric, homo- and hetero-multimeric, chromophore-containing and chromophore-free, and alpha-helical and beta-barrel proteins.
CAS Registry Number is a Registered Trademark of the American Chemical Society
1-8Z-monoheptenoin
Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. Protein and lipid interactions driving molecular mechanisms of in meso crystallization. J Am Chem Soc. 2014 Feb 26;136(8):3271-84. doi: 10.1021/ja4129839. Epub 2014 Feb 14. PMID: 24494670; PMCID: PMC3985912.
PubMed ID: 24494670Caffrey M, Porter C. Crystallizing membrane proteins for structure determination using lipidic mesophases. J Vis Exp. 2010 Nov 21;(45):1712. doi: 10.3791/1712. PMID: 21113125; PMCID: PMC3144658.
PubMed ID: 21113125Caffrey M, Cherezov V. Crystallizing membrane proteins using lipidic mesophases. Nat Protoc. 2009;4(5):706-31. doi: 10.1038/nprot.2009.31. PMID: 19390528; PMCID: PMC2732203.
PubMed ID: 19390528Höfer N, Aragão D, Caffrey M. Crystallizing transmembrane peptides in lipidic mesophases. Biophys J. 2010 Aug 4;99(3):L23-5. doi: 10.1016/j.bpj.2010.05.011. PMID: 20682243; PMCID: PMC2913208.
PubMed ID: 20682243Misquitta LV, Misquitta Y, Cherezov V, Slattery O, Mohan JM, Hart D, Zhalnina M, Cramer WA, Caffrey M. Membrane protein crystallization in lipidic mesophases with tailored bilayers. Structure. 2004 Dec;12(12):2113-24. doi: 10.1016/j.str.2004.09.020. PMID: 15576026.
PubMed ID: 15576026- Certificate of Analysis (Lot No. 850543P-25MG-A-016 and 5722PJA016)
- Certificate of Analysis (Lot No. 850543P-25MG-B-016 and 5722PJB016)
- Certificate of Analysis (Lot No. 850543P-200MG-A-016 and 5722PNA016)
- Certificate of Analysis (Lot No. 850543P-200MG-A-017 and 5722PNA017)