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850520 | n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside

n-dodecyl-ß-D-maltoside (DDM)

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Size SKU Packaging Price
1g 850520P-1g 850520P-1g 1 x 1g $159.71
5g 850520P-5g 850520P-5g 1 x 5g $586.55
25g 850520P-25g 850520P-25g 1 x 25g $2,225.75
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Info

n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside

n-dodecyl-ß-D-maltoside (DDM), or n-dodecyl-β-D-maltopyranoside, is a high-purity, non-ionic detergent extensively used to study the solubilization, stabilization, and structure of membrane proteins. Unlike harsh detergents that can denature proteins, DDM gently disrupts lipid bilayers while preserving protein functionality. This has made it an essential tool in biochemistry, structural biology, and pharmaceutical research.

With a low critical micelle concentration (CMC) of approximately 0.17 mM and a high aggregation number, DDM forms exceptionally stable micelles that enhance protein solubility and long-term stability. Its mild amphiphilic nature makes it a preferred detergent in cryo-EM, X-ray crystallography, and NMR studies—where maintaining native protein confirmation is highly important.

Application

DDM is widely used for isolating and purifying membrane proteins—including G-protein coupled receptors (GPCRs) and ion channels—to ensure structural integrity and functional activity. It’s frequently used in X-ray crystallography, nuclear magnetic resonance (NMR), and electron microscopy to facilitate high-resolution structural analysis.

Another notable characteristic of n-dodecyl-β-D-maltopyranoside is its ability to support the formation of proteoliposomes and model membrane systems to aid in studying lipid-protein interactions. Additionally, it improves the solubility and activity of enzymes such as lipases, ATPases, and cytochrome complexes, improving assay reliability and reproducibility.

Packaging

Avanti Research™ provides n-dodecyl-ß-D-maltoside (DDM) in powder (1g, 5g, and 25g) with the ability to support your experimental and formulation needs.

With 50+ years of expertise producing high-quality lipids and detergents, Avanti ensures reliable and consistent products to support your research and development.

Visit Croda Pharma to explore a diverse selection of GMP-grade reagents, carefully qualified to meet the rigorous standards of large-scale pharmaceutical manufacturing.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C24H46O11
Percent Composition
C 56.45%, H 9.08%, O 34.47%
Purity
>99%; contains <2% alpha isomer
Stability
1 Years
Storage Temperature
-20°C
CAS Number
69227-93-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
510.615
Exact Mass
510.304
Synonyms
DDM
lauryl maltosidedodecyl
4-O-α-D-glucopyranosyl-β-D-glucopyranoside
770520
CMC
~0.2 mM
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References

Carey Hulyer AR, Briggs DA, O'Mara ML, Kerr ID, Harmer JR, Callaghan R. Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane. J Struct Biol. 2020 Apr 24:107513. doi: 10.1016/j.jsb.2020.107513. Epub ahead of print. PMID: 32339763.

 PubMed ID: 32339763

Do T, Schaefer K, Santiago AG, Coe KA, Fernandes PB, Kahne D, Pinho MG, Walker S. Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan. Nat Microbiol. 2020 Feb;5(2):291-303. doi: 10.1038/s41564-019-0632-1. Epub 2020 Jan 13. PMID: 31932712.

 PubMed ID: 31932712

Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Rieke F, Craig AM, Wong RO, Hoon M. LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells. Neuron. 2020 Jan 8:S0896-6273(19)31094-3. doi: 10.1016/j.neuron.2019.12.028. Epub ahead of print. PMID: 31974009.

 PubMed ID: 31974009

Roppongi RT, Dhume SH, Padmanabhan N, Silwal P, Zahra N, Karimi B, Bomkamp C, Patil CS, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MF, Siddiqui TJ. LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ. Neuron. 2020 Jan 23:S0896-6273(20)30003-9. doi: 10.1016/j.neuron.2020.01.003. Epub ahead of print. PMID: 31995730.

 PubMed ID: 31995730

Ghysels A, Krämer A, Venable RM, Teague WE Jr, Lyman E, Gawrisch K, Pastor RW. Permeability of membranes in the liquid ordered and liquid disordered phases. Nat Commun. 2019 Dec 9;10(1):5616. doi: 10.1038/s41467-019-13432-7.

 PubMed ID: 31811124

Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E698-704. doi: 10.1073/pnas.1201107109. Epub 2012 Feb 21.

 PubMed ID: 22355148

Thompson, A.A., J.J. Liu, E. Chun, D. Wacker, H. Wu, V. Cherezov, and R.C. Stevens. (2011). GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods 55:310-7. doi: 10.1016/j.ymeth.2011.10.011

 PubMed ID: 22041719
Certificates of Analysis

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