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850398 | 22:1 (Cis) PC (DEPC)

1,2-dierucoyl-sn-glycero-3-phosphocholine

22:1 (Cis) PC (DEPC)

Chloroform

Size SKU Packaging Price
25mg 850398C-25mg 850398C-25mg 1 x 25mg 10mg/mL 2.5mL $133.75
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Powder

Size SKU Packaging Price
25mg 850398P-25mg 850398P-25mg 1 x 25mg $133.75 133.75
Request Bulk Pricing
Info

22:1 (Cis) PC (DEPC)

1,2-dierucoyl-sn-glycero-3-phosphocholine

1,2-dierucoyl-sn-glycero-3-phosphocholine, or 22:1 (Cis) PC (DEPC), is an unsaturated phospholipid featuring 22-carbon monounsaturated acyl chains with a cis double bond. DEPC has a low phase transition temperature of about –15–20°C. For this reason, it is commonly used in liposome formulations, membrane fluidity studies, and protein-lipid interaction research.

Applications

As a crucial piece of long-circulating liposomes and nanoparticles, DEPC ensures enhanced stability and efficient drug/gene delivery. Additionally, it models highly fluid membranes by supporting lipid raft formation, domain organization, and lateral diffusion studies. Another notable characteristic of 22:1 (Cis) PC (DEPC) is its high membrane flexibility, which helps facilitate ion channel studies, transmembrane protein integration, and structural lipid research.

Additionally, this phospholipid helps understand membrane mechanics, making it critical in bilayer fusion, permeability studies, and vesicle stability research.

Packaging

Avanti Research™ offers 22:1 (Cis) PC (DEPC) in 25mg packaging in powder and chloroform to accommodate a variety of research applications.

Our commitment to uncompromising purity ensures your research is conducted with the highest quality phospholipids for breakthrough results!

As a Croda Pharma brand, Avanti Research is your partner from research innovation to GMP excellence. Visit Croda Pharma for GMP-certified DEPC and other pharmaceutical-grade lipid solutions to advance your research to the next level.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C52H100NO8P
Percent Composition
C 69.52%, H 11.22%, N 1.56%, O 14.25%, P 3.45
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
51779-95-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
898.326
Exact Mass
897.719
Synonyms
1,2-di-(13Z-docosenoyl)-sn-glycero-3-phosphocholine
PC(22:1(13Z)/22:1(13Z))
DEPC
730398
Transition Temp
13.2°C
Downloads
References

Greathouse D, Lipinski K, McKay MJ, Afrose F, Martfeld AN, Koeppe RE 2nd. Influence of Lipid Saturation, Hydrophobic Length and Cholesterol on Double-Arginine-Containing Helical Peptides in Bilayer Membranes. Chembiochem. 2019 May 31. doi: 10.1002/cbic.201900282. [Epub ahead of print]

 PubMed ID: 31150136

Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S. Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 15;1864(10):1350-1362. doi: 10.1016/j.bbalip.2019.06.010. [Epub ahead of print]

 PubMed ID: 31207356

Gutzeit VA, Thibado J, Stor DS, Zhou Z, Blanchard SC, Andersen OS, Levitz J. Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. Elife. 2019 Jun 7;8. pii: e45116. doi: 10.7554/eLife.45116.

 PubMed ID: 31172948

Forest A, Ruiz M, Bouchard B, Boucher G, Gingras O, Daneault C, Robillard Frayne I, Rhainds D, Consortium TI, Genetics Consortium TNI, Tardif JC, Rioux JD, Des Rosiers C. A Comprehensive and Reproducible Untargeted Lipidomic Workflow Using LC-QTOF Validated for Human Plasma Analysis. J Proteome Res. 2018 Sep 26. doi: 10.1021/acs.jproteome.8b00270. [Epub ahead of print]

 PubMed ID: 30256116
Certificates of Analysis

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