850360 | 17:0 PC

1,2-diheptadecanoyl-sn-glycero-3-phosphocholine

17:0 PC

Powder

Size SKU Packaging Price
25mg 850360P-25mg 850360P-25mg 1 x 25mg $136.50
200mg 850360P-200mg 850360P-200mg 1 x 200mg $258.00
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Chloroform

Size SKU Packaging Price
25mg 850360C-25mg 850360C-25mg 1 x 25mg 10mg/mL 2.5mL $136.50 136.5
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Info

17:0 PC

1,2-diheptadecanoyl-sn-glycero-3-phosphocholine

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC's. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H84NO8P
Percent Composition
C 66.19%, H 11.11%, N 1.84%, O 16.79%, P 4.06%
Purity
>99%
Stability
2 years
Storage Temperature
-20°C
CAS Number
70897-27-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
762.092
Exact Mass
761.593
Synonyms
PC(17:0/17:0)
Transition Temp
50°C
References

Farhat E, Devereaux MEM, Pamenter ME, Weber JM. Naked mole-rats suppress energy metabolism and modulate membrane cholesterol in chronic hypoxia. Am J Physiol Regul Integr Comp Physiol. 2020 Aug 1;319(2):R148-R155. doi: 10.1152/ajpregu.00057.2020. Epub 2020 Jun 17. PMID: 32663032.

PubMed ID: 32663032

Bouillet B, Gautier T, Denimal D, Samson M, Masson D, Pais de Barros JP, Maquart G, Xolin M, Grosfeld A, Dalle H, Vergès B, Moldes M, Fève B. Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration - a proof of concept. Eur J Endocrinol. 2020 Jun 1:EJE-20-0477. doi: 10.1530/EJE-20-0477. Epub ahead of print. PMID: 32570209.

PubMed ID: 32570209

Lapidot-Cohen T, Rosental L, Brotman Y. Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Analysis for Lipophilic Compound Profiling in Plants. Curr Protoc Plant Biol. 2020 Jun;5(2):e20109. doi: 10.1002/cppb.20109. PMID: 32343495.

PubMed ID: 32343495

Sowell KD, Holt RR, Uriu-Adams JY, Chambers CD, Coles CD, Kable JA, Yevtushok L, Zymak-Zakutnya N, Wertelecki W, Keen CL; CIFASD. Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders. J Am Coll Nutr. 2020 Mar-Apr;39(3):249-260. doi: 10.1080/07315724.2020.1737984. Epub 2020 Apr 2. PMID: 32240041.

PubMed ID: 32240041

Dazzoni R, Buré C, Morvan E, Grélard A, Gounou C, Schmitter JM, Loquet A, Larijani B, Dufourc EJ. Tandem NMR and Mass Spectrometry Analysis of Human Nuclear Membrane Lipids. Anal Chem. 2020 May 19;92(10):6858-6868. doi: 10.1021/acs.analchem.9b05052. Epub 2020 May 6. PMID: 32324380.

PubMed ID: 32324380

Sehl A, Couëdelo L, Vaysse C, Cansell M. Intestinal bioavailability of n-3 long-chain polyunsaturated fatty acids influenced by the supramolecular form of phospholipids. Food Funct. 2020 Feb 26;11(2):1721-1728. doi: 10.1039/c9fo02953b. PMID: 32040103.

PubMed ID: 32040103

Sou K, Chan LY, Arai S, Lee CK. Highly cooperative fluorescence switching of self-assembled squaraine dye at tunable threshold temperatures using thermosensitive nanovesicles for optical sensing and imaging. Sci Rep. 2019 Nov 29;9(1):17991. doi: 10.1038/s41598-019-54418-1. PMID: 31784685; PMCID: PMC6884458.

PubMed ID: 31784685

Gaggini M, Carli F, Rosso C, Younes R, D'Aurizio R, Bugianesi E, Gastaldelli A. Altered Metabolic Profile and Adipocyte Insulin Resistance Mark Severe Liver Fibrosis in Patients with Chronic Liver Disease. Int J Mol Sci. 2019 Dec 16;20(24):6333. doi: 10.3390/ijms20246333. PMID: 31888144; PMCID: PMC6940758.

PubMed ID: 31888144

Perez de Souza L, Alseekh S, Naake T, Fernie A. Mass Spectrometry-Based Untargeted Plant Metabolomics. Curr Protoc Plant Biol. 2019 Dec;4(4):e20100. doi: 10.1002/cppb.20100.

PubMed ID: 31743625

Guo XF, Tong WF, Ruan Y, Sinclair AJ, Li D. Different metabolism of EPA, DPA and DHA in humans: A double-blind cross-over study. Prostaglandins Leukot Essent Fatty Acids. 2019 Nov 12:102033. doi: 10.1016/j.plefa.2019.102033. [Epub ahead of print]

PubMed ID: 31740197

Bogusławska J, Popławski P, Alseekh S, Koblowska M, Iwanicka-Nowicka R, Rybicka B, Kędzierska H, Głuchowska K, Hanusek K, Tański Z, Fernie AR, Piekiełko-Witkowska A. MicroRNA-Mediated Metabolic Reprograming in Renal Cancer. Cancers (Basel). 2019 Nov 20;11(12). pii: E1825. doi: 10.3390/cancers11121825.

PubMed ID: 31756931

Chamberlain CA, Hatch M, Garrett TJ. Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri. PLoS One. 2019 Sep 23;14(9):e0222393. doi: 10.1371/journal.pone.0222393. eCollection 2019.

PubMed ID: 31545840

Furtado JD, Beqari J, Campos H. Comparison of the Utility of Total Plasma Fatty Acids Versus those in Cholesteryl Ester, Phospholipid, and Triglyceride as Biomarkers of Fatty Acid Intake. Nutrients. 2019 Sep 3;11(9). pii: E2081. doi: 10.3390/nu11092081.

PubMed ID: 31484459

Farhat E, Turenne ED, Choi K, Weber JM. Hypoxia-induced remodelling of goldfish membranes. Comp Biochem Physiol B Biochem Mol Biol. 2019 Nov;237:110326. doi: 10.1016/j.cbpb.2019.110326. Epub 2019 Aug 26.

PubMed ID: 31465877

Zhang TT, Xu J, Wang YM, Xue CH. Health benefits of dietary marine DHA/EPA-enriched glycerophospholipids. Prog Lipid Res. 2019 Jul;75:100997. doi: 10.1016/j.plipres.2019.100997. Epub 2019 Aug 20.

PubMed ID: 31442526

Visscher M, Moerman AM, Burgers PC, Van Beusekom HMM, Luider TM, Verhagen HJM, Van der Steen AFW, Van der Heiden K, Van Soest G. Data Processing Pipeline for Lipid Profiling of Carotid Atherosclerotic Plaque with Mass Spectrometry Imaging. J Am Soc Mass Spectrom. 2019 Sep;30(9):1790-1800. doi: 10.1007/s13361-019-02254-y. Epub 2019 Jun 27.

PubMed ID: 31250318

Myers WA, Rico JE, Davis AN, Fontoura ABP, Dineen MJ, Tate BN, McFadden JW. Effects of abomasal infusions of fatty acids and one-carbon donors on hepatic ceramide and phosphatidylcholine in lactating Holstein dairy cows. J Dairy Sci. 2019 Aug;102(8):7087-7101. doi: 10.3168/jds.2018-16200. Epub 2019 Jun 6.

PubMed ID: 31178188

Hehlert P, Hofferek V, Heier C, Eichmann TO, Riedel D, Rosenberg J, Takaćs A, Nagy HM, Oberer M, Zimmermann R, Kühnlein RP. The α/β-hydrolase domain-containing 4 and 5 (ABHD4/5)-related phospholipase Pummelig controls energy storage in Drosophila. J Lipid Res. 2019 Jun 4. pii: jlr.M092817. doi: 10.1194/jlr.M092817. [Epub ahead of print]

PubMed ID: 31164391

Schilcher I, Ledinski G, Radulović S, Hallström S, Eichmann T, Madl T, Zhang F, Leitinger G, Kolb-Lenz D, Darnhofer B, Birner-Gruenberger R, Wadsack C, Kratky D, Marsche G, Frank S, Cvirn G. Endothelial lipase increases antioxidative capacity of high-density lipoprotein. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 17;1864(10):1363-1374. doi: 10.1016/j.bbalip.2019.06.011. [Epub ahead of print]

PubMed ID: 31220617

Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. 2019 Jun 25:1-20. doi: 10.1080/15548627.2019.1628538. [Epub ahead of print]

PubMed ID: 31238788

Shimba Y, Togawa H, Senoo N, Ikeda M, Miyoshi N, Morita A, Miura S. Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice. Sci Rep. 2019 Mar 11;9(1):4077. doi: 10.1038/s41598-019-40643-1.

PubMed ID: 30858489

Werthebach M, Stewart FA, Gahlen A, Mettler-Altmann T, Akhtar I, Maas-Enriquez K, Droste A, Eichmann TO, Poschmann G, Stühler K, Beller M. Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf. Cell Rep. 2019 Mar 26;26(13):3726-3740.e7. doi: 10.1016/j.celrep.2019.02.110.

PubMed ID: 30917324

Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, Rundstedt FV, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Andrea AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1B effect on fatty acid metabolism in Bladder Cancer. Clin Cancer Res. 2019 Mar 7. pii: clincanres.1515.2018. doi: 10.1158/1078-0432.CCR-18-1515. [Epub ahead of print]

PubMed ID: 30846479

Žáček P, Bukowski M, Mehus A, Johnson L, Zeng H, Raatz S, Idso JP, Picklo M. Dietary saturated fatty acid type impacts obesity-induced metabolic dysfunction and plasma lipidomic signatures in mice. J Nutr Biochem. 2019 Feb;64:32-44. doi: 10.1016/j.jnutbio.2018.10.005. Epub 2018 Oct 21.

PubMed ID: 30428423

Zhu X, Gan-Schreier H, Otto AC, Cheng Y, Staffer S, Tuma-Kellner S, Ganzha A, Liebisch G, Chamulitrat W. iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):677-687. doi: 10.1016/j.bbalip.2019.02.003. Epub 2019 Feb 5.

PubMed ID: 30735854

Nyamugenda E, Trentzsch M, Russell S, Miles T, Boysen G, Phelan KD, Baldini G. Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice. J Neurochem. 2019 Jan 7. doi: 10.1111/jnc.14662. [Epub ahead of print]

PubMed ID: 30615192

Yalagala PC, Sugasini D, Dasarathi S, Pahan K, Subbaiah PV. Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: Potential treatment for depression. J Lipid Res. 2018 Dec 10. pii: jlr.M090464. doi: 10.1194/jlr.M090464. [Epub ahead of print].

PubMed ID: 30530735

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J. Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling. Dev Cell. 2018 Oct 8;47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. Epub 2018 Sep 27.

PubMed ID: 30269951

Gathungu RM, Larrea P, Sniatynski MJ, Marur VR, Bowden JA, Koelmel JP, Starke-Reed P, Hubbard VS, Kristal BS. Optimization of Electrospray Ionization Source Parameters for Lipidomics To Reduce Misannotation of In-Source Fragments as Precursor Ions. Anal Chem. 2018 Nov 2. doi: 10.1021/acs.analchem.8b03436. [Epub ahead of print]

PubMed ID: 30265528
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