Section Menu

840465 | 18:0 PG

1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)

18:0 PG

Powder

Size SKU Packaging Price
25mg 840465P-25mg 840465P-25mg 1 x 25mg $94.25
200mg 840465P-200mg 840465P-200mg 1 x 200mg $276.00
1g 840465P-1g 840465P-1g 1 x 1g $711.02
Request Bulk Pricing
Info

18:0 PG

1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)

18:0 PG

18:0 PG, also known as 1,2-distearoyl-sn-glycero-3-phospho-(1′-rac-glycerol)(sodium salt), is a phosphatidylglycerol (PG) derived from a L-glycerol 3-phosphate backbone structure and is ester-bonded to saturated fatty acids on carbons 1 and 2. It makes up a minor portion (1–2%) of most cell membranes.

Phosphatidylglycerols are phospholipids where glycerol forms ester bonds with the phosphate polar head group. PGs carry a negative charge under physiological pH conditions.

Application

Phosphatidylglycerol is a key component of lung surfactant, comprising up to 11% of total lipid content. It is used to assess fetal lung maturity and serves as a marker for assessing fetal fitness in clinical settings. It also aids in cardiolipin synthesis, an essential lipid for cellular function. The presence of PG in a bacterial membrane can reach up to 20%.

Packaging

Avanti Research offers 18:0 PG in powder form in 25 mg, 200 mg, and 1 g packaging. Ensure stability, purity, and reliability in your lipids research and development when you partner with Avanti Research.


Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H82O10PNa
Percent Composition
C 62.97%, H 10.32%, Na 2.87%, O 19.97%, P 3.87%
Purity
>99%
Stability
Powder 1 year; Solution 6 mo.
Storage Temperature
-20°C
CAS Number
200880-42-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
801.058
Exact Mass
800.554
Synonyms
1,2-dioctadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)
DSPG
PG(18:0/18:0)
110649
730465
Transition Temp
55°C
Solubility in Different Solvents
Insoluble in ethanol and DMSO, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL
Downloads
References

Cimorelli M, Flynn MA, Angel B, Fafarman A, Kohut A, Wrenn S. An Ultrasound Enhancing Agent with Nonlinear Acoustic Activity that Depends on the Presence of an Electric Field. Ultrasound Med Biol. 2020 Jun 29:S0301-5629(20)30242-8. doi: 10.1016/j.ultrasmedbio.2020.04.038. Epub ahead of print. PMID: 32616427.

 PubMed ID: 32616427

Kessenich BL, Pokhrel N, Kibue JK, Flury M, Maibaum L, De Yoreo JJ. Negatively Charged Lipids Exhibit Negligible Effects on the Water Repellency of Montmorillonite Films. ACS Omega. 2020 May 15;5(21):12154-12161. doi: 10.1021/acsomega.0c00499. PMID: 32548396; PMCID: PMC7271367.

 PubMed ID: 32548396

Vera-González N, Bailey-Hytholt CM, Langlois L, de Camargo Ribeiro F, de Souza Santos EL, Junqueira JC, Shukla A. Anidulafungin liposome nanoparticles exhibit antifungal activity against planktonic and biofilm Candida albicans. J Biomed Mater Res A. 2020 May 3. doi: 10.1002/jbm.a.36984. Epub ahead of print. PMID: 32363762.

 PubMed ID: 32363762

Mutlu-Agardan NB, Yilmaz S, Kaynak Onurdag F, Celebi N. Development of effective AmB/AmB-αCD complex double loaded liposomes using a factorial design for systemic fungal infection treatment. J Liposome Res. 2020 May 21:1-12. doi: 10.1080/08982104.2020.1755980. Epub ahead of print. PMID: 32290745.

 PubMed ID: 32290745

Zamani P, Navashenaq JG, Teymouri M, Karimi M, Mashreghi M, Jaafari MR. Combination therapy with liposomal doxorubicin and liposomal vaccine containing E75, an HER-2/neu-derived peptide, reduces myeloid-derived suppressor cells and improved tumor therapy. Life Sci. 2020 Jul 1;252:117646. doi: 10.1016/j.lfs.2020.117646. Epub 2020 Apr 7. PMID: 32272178.

 PubMed ID: 32272178

Visvabharathy L, Genardi S, Cao L, He Y, Alonzo F 3rd, Berdyshev E, Wang CR. Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection. PLoS Pathog. 2020 Apr 28;16(4):e1008443. doi: 10.1371/journal.ppat.1008443. PMID: 32343740; PMCID: PMC7188215.

 PubMed ID: 32343740

Zamani P, Teymouri M, Nikpoor AR, Navashenaq JG, Gholizadeh Z, Darban SA, Jaafari MR. Nanoliposomal vaccine containing long multi-epitope peptide E75-AE36 pulsed PADRE-induced effective immune response in mice TUBO model of breast cancer. Eur J Cancer. 2020 Apr;129:80-96. doi: 10.1016/j.ejca.2020.01.010. Epub 2020 Mar 4. PMID: 32145473.

 PubMed ID: 32145473

Wu CY, Huang RY, Liao EC, Lin YC, Ho YJ, Chang CW, Chan HL, Huang YZ, Hsieh TH, Fan CH, Yeh CK. A preliminary study of Parkinson's gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice. Brain Stimul. 2020 Feb 24;13(3):786-799. doi: 10.1016/j.brs.2020.02.024. Epub ahead of print. PMID: 32289709.

 PubMed ID: 32289709

Benne N, Leboux RJT, Glandrup M, van Duijn J, Lozano Vigario F, Neustrup MA, Romeijn S, Galli F, Kuiper J, Jiskoot W, Slütter B. Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses. J Control Release. 2019 Dec 5;318:246-255. doi: 10.1016/j.jconrel.2019.12.003. [Epub ahead of print]. PMID: 31812539.

 PubMed ID: 31812539

Van Haute D, Jiang W, Mudalige T. Evaluation of size-based distribution of drug and excipient in amphotericin B liposomal formulation. Int J Pharm. 2019 Oct 5;569:118603. doi: 10.1016/j.ijpharm.2019.118603. Epub 2019 Aug 8.

 PubMed ID: 31401296

Deshpande S, Wunnava S, Hueting D, Dekker C. Membrane Tension-Mediated Growth of Liposomes. Small. 2019 Sep;15(38):e1902898. doi: 10.1002/smll.201902898. Epub 2019 Jul 31.

 PubMed ID: 31365179

Gilabert-Oriol R, Sutherland BW, Anantha M, Pallaoro A, Bally MB. Liposomal OTS964, a TOPK inhibitor: a simple method to estimate OTS964 association with liposomes that relies on enhanced OTS964 fluorescence when bound to albumin. Drug Deliv Transl Res. 2019 Jun 17. doi: 10.1007/s13346-019-00651-0. [Epub ahead of print]

 PubMed ID: 31209826

Marazioti A, Papadia K, Giannou A, Stathopoulos GT, Antimisiaris SG. Prolonged retention of liposomes in the pleural cavity of normal mice and high tumor distribution in mice with malignant pleural effusion, after intrapleural injection. Int J Nanomedicine. 2019 May 23;14:3773-3784. doi: 10.2147/IJN.S202568. eCollection 2019.

 PubMed ID: 31213801

Kuo TT, Wang CH, Wang JY, Chiou HJ, Fan CH, Yeh CK. Concurrent Osteosarcoma Theranostic Strategy Using Contrast-Enhanced Ultrasound and Drug-Loaded Bubbles. Pharmaceutics. 2019 May 8;11(5). pii: E223. doi: 10.3390/pharmaceutics11050223.

 PubMed ID: 31071997

Korani M, Ghaffari S, Attar H, Mashreghi M, Jaafari MR. Preparation and characterization of nanoliposomal bortezomib formulations and evaluation of their anti-cancer efficacy in mice bearing C26 colon carcinoma and B16F0 melanoma. Nanomedicine. 2019 May 16;20:102013. doi: 10.1016/j.nano.2019.04.016. [Epub ahead of print]

 PubMed ID: 31103736

Lolicato F, Joly L, Martinez-Seara H, Fragneto G, Scoppola E, Baldelli Bombelli F, Vattulainen I, Akola J, Maccarini M. The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers. Small. 2019 Jun;15(23):e1805046. doi: 10.1002/smll.201805046. Epub 2019 Apr 23.

 PubMed ID: 31012268

Odette WL, Payne NA, Khaliullin RZ, Mauzeroll J. Redox-Triggered Disassembly of Nanosized Liposomes Containing Ferrocene-Appended Amphiphiles. Langmuir. 2019 Apr 23;35(16):5608-5616. doi: 10.1021/acs.langmuir.8b04267. Epub 2019 Apr 12.

 PubMed ID: 30916976

Correa S, Boehnke N, Deiss-Yehiely E, Hammond PT Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes. ACS Nano. 2019 Apr 18. doi: 10.1021/acsnano.9b00792. [Epub ahead of print]

 PubMed ID: 30986034

Farzad N, Barati N, Momtazi-Borojeni AA, Yazdani M, Arab A, Razazan A, Shariat S, Mansourian M, Abbasi A, Saberi Z, Badiee A, Jalali SA, Jaafari MR. P435 HER2/neu-derived peptide conjugated to liposomes containing DOPE as an effective prophylactic vaccine formulation for breast cancer. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):665-673. doi: 10.1080/21691401.2019.1576702.

 PubMed ID: 30829072

Odette WL1, Payne NA1, Khaliullin RZ1, Mauzeroll J1. Redox-Triggered Disassembly of Nanosized Liposomes Containing Ferrocene-Appended Amphiphiles. Langmuir. 2019 Apr 12. doi: 10.1021/acs.langmuir.8b04267. [Epub ahead of print]

 PubMed ID: 30916976

Ogawa K, Fuchigami Y, Hagimori M, Fumoto S, Maruyama K, Kawakami S. Ultrasound-responsive nanobubble-mediated gene transfection in the cerebroventricular region by intracerebroventricular administration in mice. Eur J Pharm Biopharm. 2019 Apr;137:1-8. doi: 10.1016/j.ejpb.2019.02.003. Epub 2019 Feb 7

 PubMed ID: 30738859

Pang X, Xiao Q, Cheng Y, Ren E, Lian L, Zhang Y, Gao H, Wang X, Leung W, Chen X, Liu G, Xu C. Bacteria-Responsive Nanoliposomes as Smart Sonotheranostics for Multidrug Resistant Bacterial Infections. ACS Nano. 2019 Feb 26;13(2):2427-2438. doi: 10.1021/acsnano.8b09336. Epub 2019 Jan 24.

 PubMed ID: 30657302

Zhu Z, Shen J, Wang D, Chen C, Xu Y, Guo H, Kang D, Hamada N, Dong J, Wang G, Liang Y. An auxiliary matrix for routine analysis of small molecules and biological macromolecules using matrix-assisted laser desorption ionization mass spectrometry. Anal Bioanal Chem. 2019 Feb;411(5):1041-1052. doi: 10.1007/s00216-018-1532-6. Epub 2019 Jan 7.

 PubMed ID: 30613842

Unga J, Omata D, Kudo N, Ueno S, Munakata L, Shima T, Suzuki R, Maruyama K. Development and evaluation of stability and ultrasound response of DSPC-DPSG-based freeze-dried microbubbles. J Liposome Res. 2018 Dec 10:1-7. doi: 10.1080/08982104.2018.1556294. [Epub ahead of print].

 PubMed ID: 30526185

Pang X, Xiao Q, Cheng Y, Ren E, Lian L, Zhang Y, Gao H, Wang X, Leung W, Chen X, Liu G, Xu C. Bacteria-Responsive Nanoliposomes as Smart Sonotheranostics for Multidrug Resistant Bacterial Infections. ACS Nano. 2019 Jan 18. doi: 10.1021/acsnano.8b09336. [Epub ahead of print]

 PubMed ID: 30657302
Certificates of Analysis

Related Products

840492
22:6 PG 22:6 PG Buy Now
840490
20:4 PG 20:4 PG Buy Now
840487
18:3 PG 18:3 PG Buy Now
840485
18:2 PG 18:2 PG Buy Now

Cart

Item Price Qty.
${ item.sku }
Base Price: $${ (item.price - (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150))).toFixed(2) }
Custom Packaging: +${ (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150)).toFixed(2) }
Change Custom Packaging 		$ ${ item.total.toFixed(2) }
Subtotal: ${ cart.itemSubtotal|money }
${ adjustment.name } ${ adjustment.amountAsCurrency }
Order Total: ${ cart.totalPriceAsCurrency }
Finalize Cart