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840445 | 14:0 PG

1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)

14:0 PG

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Size SKU Packaging Price
25mg 840445P-25mg 840445P-25mg 1 x 25mg $94.25
200mg 840445P-200mg 840445P-200mg 1 x 200mg $276.00
500mg 840445P-500mg 840445P-500mg 1 x 500mg $465.00
1g 840445P-1g 840445P-1g 1 x 1g $711.02
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Info

14:0 PG

1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)

14:0 PG

14:0 PG or 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol), sodium salt (DMPG) is a form of phosphoglyceride (PG), a minor component (only one to two percent) of most cell membranes. Phosphoglyceride (PG), also known as glycerophospholipid, forms an essential component of membrane bilayers, including up to 20 percent of bacterial membranes across diverse biological systems.

14:0 PG is integral to cellular membranes, with its unique structure consisting of a three-carbon glycerol backbone, two long-chain fatty acids, esterified to hydroxyl groups on carbons 1 and 2 of the glycerol, and phosphoric acid esterified to the C3 hydroxyl group of glycerol. PG is abundant in all cell membranes and is present in minimal quantities in fat reserves. It's used by cells as part of the transition to cardiolipin synthesis.

Additionally, PG can be detected at higher concentrations (up to 11 percent of the total lipid content) within lung surfactants. Its presence in amniotic fluid serves as an indicator of fetal lung maturity and forms the foundation of clinical testing for fetal fitness.

Application

This phospholipid serves various research purposes, including preparing lipid bicelles for nuclear magnetic resonance (NMR) experiments and facilitating detailed structural analyses. Additionally, it can be used as a phospholipid (PL) standard for accurately quantifying phosphatidylglycerol via chromatography to ensure precise measurements. Furthermore, researchers utilize 14:0 PG in crafting DMPG (l-dimyristoylphosphatidylglycerol) phospholipid vesicles, enabling the investigation of the inner workings of cell membranes.

Packaging

Give your research a solid foundation with 14:0 PG from Avanti. Available in powder form in 25 mg, 200 mg, 500 mg, and 1 g packaging. With over 50 years of creating the highest-purity lipids on the market, the Avanti standard is the best there is.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H66O10PNa
Percent Composition
C 59.28%, H 9.66%, Na 3.34%, O 23.23%, P 4.50%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
200880-40-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
688.845
Exact Mass
688.429
Synonyms
1,2-ditetradecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)
DMPG
PG(14:0/14:0)
110648
730445
Transition Temp
23°C
Solubility in Different Solvents
Insoluble in ethanol, soluble in DMSO and Chloroform:Methanol:Water (65:25:4) at 5mg/mL
CMC
0.011mM
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F. Varenne, J.-B.Coty, J.Botton, F.-X. Legrand, H. Hillaireau, G. Barratt, C. Vauthier. Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes. Talanta. 1 December 2019;205:120062. doi: 10.1016/j.talanta.2019.06.062.

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Janke U, Kulke M, Buchholz I, Geist N, Langel W, Delcea M. Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes. PLoS One. 2019 Apr 12;14(4):e0214969. doi: 10.1371/journal.pone.0214969. eCollection 2019.

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Nielsen JE, Lind TK, Lone A, Gerelli Y, Hansen PR, Jenssen H, Cárdenas M, Lund R. A biophysical study of the interactions between the antimicrobial peptide indolicidin and lipid model systems. Biochim Biophys Acta Biomembr. 2019 Apr 9;1861(7):1355-1364. doi: 10.1016/j.bbamem.2019.04.003. [Epub ahead of print]

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Dadhich R, Singh A, Menon AP, Mishra M, Athul CD, Kapoor S. Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis. Biochim Biophys Acta Biomembr. 2019 Jun 1;1861(6):1213-1227. doi: 10.1016/j.bbamem.2019.04.004. Epub 2019 Apr 17.

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Sett R, Paul BK, Guchhait N. Unsaturation of the phospholipid side-chain influences its interaction with cyclodextrins: A spectroscopic exploration using a phenazinium dye. Colloids Surf B Biointerfaces. 2019 Apr 23;180:150-158. doi: 10.1016/j.colsurfb.2019.04.046. [Epub ahead of print]

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Sarkar N, Bose S. Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering. ACS Appl Mater Interfaces. 2019 May 15;11(19):17184-17192. doi: 10.1021/acsami.9b01218. Epub 2019 May 1.

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Zamani P, Navashenaq JG, Nikpoor AR, Hatamipour M, Oskuee RK, Badiee A, Jaafari MR. MPL nano-liposomal vaccine containing P5 HER2/neu-derived peptide pulsed PADRE as an effective vaccine in a mice TUBO model of breast cancer. J Control Release. 2019 Apr 15;303:223-236. doi: 10.1016/j.jconrel.2019.04.019. [Epub ahead of print]

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Portillo S, Zepeda BG, Iniguez E, Olivas JJ, Karimi NH, Moreira OC, Marques AF, Michael K, Maldonado RA, Almeida IC. A prophylactic α-Gal-based glycovaccine effectively protects against murine acute Chagas disease. NPJ Vaccines. 2019 Mar 22;4:13. doi: 10.1038/s41541-019-0107-7. eCollection 2019.

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Dalchand N, Doğangün M, Ohno PE, Ma E, Martinson ABF, Geiger FM. Perturbation of Hydrogen Bonding Networks Over Supported Lipid Bilayers by Poly (allylamine hydrochloride). J Phys Chem B. 2019 Apr 23. doi: 10.1021/acs.jpcb.9b02392. [Epub ahead of print]

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Wójcik A, Bieniasz A, Wydro P, Broniatowski M. The effect of chlorination degree and substitution pattern on the interactions of polychlorinated biphenyls with model bacterial membranes. Biochim Biophys Acta Biomembr. 2019 Mar 16;1861(6):1057-1068. doi: 10.1016/j.bbamem.2019.03.009. [Epub ahead of print]

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Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Certificates of Analysis

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