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840046 | Brain PI(4,5)P2

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)

Brain PI(4,5)P2

Chloroform:Methanol:Water

Size SKU Packaging Price
1mg 840046X-1mg 840046X-1mg 1 x 1mg 1mg/mL 1mL $530.45
5mg 840046X-5mg 840046X-5mg 1 x 5mg $2,186.60
10mg 840046X-10mg 840046X-10mg 1 x 10mg $3,796.80
25mg 840046X-25mg 840046X-25mg 1 x 25mg 10mg/mL 2.5mL $8,423.75
Request Bulk Pricing

Powder

Size SKU Packaging Price
1mg 840046P-1mg 840046P-1mg 1 x 1mg $530.45 530.45
5mg 840046P-5mg 840046P-5mg 1 x 5mg $2,186.60 2186.6
10mg 840046P-10mg 840046P-10mg 1 x 10mg $3,796.80 3796.8
25mg 840046P-25mg 840046P-25mg 1 x 25mg $8,423.75 8423.75
Request Bulk Pricing
Info

Brain PI(4,5)P2

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)

*Avanti also offers a fully synthetic alternative of the predominant fatty acid species 18:0-20:4 PI(4,5)P2 (850165)*


Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Data
Hygroscopic
Yes
Light Sensitive
Yes
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
383907-42-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1096.385
Synonyms
Brain PI(4,5)P2
cephalin
Solubility in Different Solvents
Insoluble in ethanol and DMSO. Soluble in 20:9:1 CMW at 5mg/mL
Downloads
References

Sun S, Liu C, Rodriguez Melendez D, Yang T, Cremer PS. Immobilization of Phosphatidylinositides Revealed by Bilayer Leaflet Decoupling. J Am Chem Soc. 2020 Jul 20. doi: 10.1021/jacs.0c03800. Epub ahead of print. PMID: 32687699.

 PubMed ID: 32687699

Fisher IJ, Jenkins ML, Tall GG, Burke JE, Smrcka AV. Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition. Structure. 2020 May 4:S0969-2126(20)30133-7. doi: 10.1016/j.str.2020.04.012. Epub ahead of print. PMID: 32402248.

 PubMed ID: 32402248

Katti S, Nyenhuis SB, Her B, Cafiso DS, Igumenova TI. Partial Metal Ion Saturation of C2 Domains Primes Synaptotagmin 1-Membrane Interactions. Biophys J. 2020 Mar 24;118(6):1409-1423. doi: 10.1016/j.bpj.2020.01.032. Epub 2020 Feb 4. PMID: 32075747; PMCID: PMC7091512.

 PubMed ID: 32075747

Tsuboi T, Lu R, Yonezawa T, Watanabe A, Woo JT, Abe-Dohmae S, Yokoyama S. Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 2020 Feb 6;297:32-39. doi: 10.1016/j.atherosclerosis.2020.01.024. Epub ahead of print. PMID: 32062137.

 PubMed ID: 32062137

Bendahmane M, Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe JM, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, Jenkins PM, Anantharam A. Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos. J Neurochem. 2020 Feb 14. doi: 10.1111/jnc.14986. Epub ahead of print. PMID: 32058590.

 PubMed ID: 32058590

Das D, Bao H, Courtney KC, Wu L, Chapman ER. Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores. Nat Commun. 2020 Jan 13;11(1):231. doi: 10.1038/s41467-019-14072-7. PMID: 31932584; PMCID: PMC6957489.

 PubMed ID: 31932584

Dornan GL, Stariha JTB, Rathinaswamy MK, Powell CJ, Boulanger MJ, Burke JE. Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases. Structure. 2019 Nov 29;S0969-2126(19)30397-1. doi: 10.1016/j.str.2019.11.013. [Epub ahead of print]. PMID: 31831213.

 PubMed ID: 31831213

Rodríguez-Fdez S, Citterio C, Lorenzo-Martín LF, Baltanás-Copado J, Llorente-González C, Corbalán-García S, Vicente-Manzanares M, Bustelo XR. Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output. Cells. 2019 Dec 16;8(12):1649. doi: 10.3390/cells8121649. PMID: 31888228; PMCID: PMC6952945.

 PubMed ID: 31888228

Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK. In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nat Commun. 2019 Aug 29;10(1):3904. doi: 10.1038/s41467-019-11873-8.

 PubMed ID: 31467284

Shukla S, Jin R, Robustelli J, Zimmerman ZE, Baumgart T. PIP2 Reshapes Membranes through Asymmetric Desorption. Biophys J. 2019 Sep 3;117(5):962-974. doi: 10.1016/j.bpj.2019.07.047. Epub 2019 Aug 5.

 PubMed ID: 31445680

Dai A, Yu L, Wang HW. WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes. Nat Commun. 2019 Aug 16;10(1):3699. doi: 10.1038/s41467-019-11694-9.

 PubMed ID: 31420534

Mahajan D, Tie HC, Chen B, Lu L. Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking. Nat Commun. 2019 Jul 19;10(1):3218. doi: 10.1038/s41467-019-11056-5.

 PubMed ID: 31324769

Valverde D, Yu, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol. 2019 Apr 5. pii: jcb.201811139. doi: 10.1083/jcb.201811139. [Epub ahead of print]

 PubMed ID: 30952800

Zhou H, Wei Z, Wang S, Yao D, Zhang R, Ma C. Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis. Cell Rep. 2019 Mar 19;26(12):3347-3359.e6. doi: 10.1016/j.celrep.2019.02.064.

 PubMed ID: 30893606

Tran HT, Anderson LH, Knight JD. Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7. Biophys J. 2019 Mar 19;116(6):1025-1036. doi: 10.1016/j.bpj.2019.01.035. Epub 2019 Feb 5.

 PubMed ID: 30795874

Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S, Bertin A. Membrane reshaping by micrometric curvature sensitive septin filaments. Nat Commun. 2019 Jan 24;10(1):420. doi: 10.1038/s41467-019-08344-5.

 PubMed ID: 30679428

Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S, Bertin A. Membrane reshaping by micrometric curvature sensitive septin filaments. Nat Commun. 2019 Jan 24;10(1):420. doi: 10.1038/s41467-019-08344-5.

 PubMed ID: 30679428

Wang S, Li Y, Gong J, Ye S, Yang X, Zhang R, Ma C. Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly. Nat Commun. 2019 Jan 8;10(1):69. doi: 10.1038/s41467-018-08028-6.

 PubMed ID: 30622273

Bai J, Tucker WC, Chapman ER. PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nat Struct Mol Biol. 2004 Jan;11(1):36-44. Epub 2003 Dec 29.

 PubMed ID: 14718921
Fatty Acid Distribution

This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

840046FattyAcidDistribution.gif
Certificates of Analysis

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