840034 | 16:0-18:1 PS (POPS)

1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (sodium salt)

16:0-18:1 PS (POPS)

Powder

Size SKU Packaging Price
10mg 840034P-10mg 840034P-10mg 1 x 10mg $114.20
25mg 840034P-25mg 840034P-25mg 1 x 25mg $177.75
200mg 840034P-200mg 840034P-200mg 2 x 100mg $908.00
500mg 840034P-500mg 840034P-500mg 5 x 100mg $1,710.00
Request Bulk Pricing

Chloroform

Size SKU Packaging Price
10mg 840034C-10mg 840034C-10mg 1 x 10mg 10mg/mL 1mL $114.20 114.2
25mg 840034C-25mg 840034C-25mg 1 x 25mg 10mg/mL 2.5mL $177.75 177.75
200mg 840034C-200mg 840034C-200mg 2 x 100mg 25mg/mL 4mL $908.00 908
500mg 840034C-500mg 840034C-500mg 5 x 100mg 25mg/mL 4mL $1,710.00 1710
Request Bulk Pricing

Info

16:0-18:1 PS (POPS)

1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (sodium salt)

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C40H75NO10PNa
Percent Composition
C 61.28%, H 9.64%, N 1.79%, Na 2.93%, O 20.41%, P 3.95%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
321863-21-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
783.988
Exact Mass
783.503
Synonyms
1-hexadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine (sodium salt)
POPS(16:0/18:1(9Z))
110669
Transition Temp
14°C
Solubility in Different Solvents
Soluble in ethanol at 5mg/mL, soluble in DMSO at 5mg/mL, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL
References

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Neves B, Domingues P, Oliveira MM, Domingues MDR, Melo T. Profile of Phosphatidylserine Modifications under Nitroxidative Stress Conditions Using a Liquid Chromatography-Mass Spectrometry Based Approach. Molecules. 2018 Dec 29;24(1). pii: E107. doi: 10.3390/molecules24010107.

PubMed ID: 30597957

Ruchala P, Waring AJ, Cilluffo M, Whitelegge JP, Gundersen CB. Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1.Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):677-684. doi: 10.1016/j.bbamem.2018.12.019. Epub 2019 Jan 4.

PubMed ID: 30615859

Florian Scheffler, Mandy Brueckner, Jingjing Ye, Ralf Seidel, and Uta Reibetanz. A Hybrid Carrier System Based on Origami Nanostrucutures and Layer‐by‐Layer Microparticles. Advanced Functional Materials. 2019 Jan 09. doi: 10.1002/adfm.201808116


He X, Zhang Q. Synthesis, Purification, and Mass Spectrometric Characterization of Stable Isotope-Labeled Amadori-Glycated Phospholipids. ACS Omega. 2018 Nov 30;3(11):15725-15733. doi: 10.1021/acsomega.8b01893. Epub 2018 Nov 19.

PubMed ID: 30533579

Li P, Wang J, Zou Y, Sun Z, Zhang M, Geng Z, Xu W, Wang D. Interaction of Hsp90AA1 with phospholipids stabilizes membranes under stress conditions. Biochim Biophys Acta Biomembr. 2019 Feb 1;1861(2):457-465. doi: 10.1016/j.bbamem.2018.11.009. Epub 2018 Dec 2.

PubMed ID: 30517848

Lawrence N, Wu B, Ligutti J, Cheneval O, Agwa AJ, Benfield AH, Biswas K, Craik DJ, Miranda LP, Troeira Henriques S, Schroeder CI. Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chem Biol. 2018 Dec 3. doi: 10.1021/acschembio.8b00989. [Epub ahead of print].

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Li Y, Soubias O, Li J1, Sun S, Randazzo PA, Byrd RA. Functional Expression and Characterization of Human Myristoylated-Arf1 in Nanodisc Membrane Mimetics. Biochemistry. 2019 Feb 20. doi: 10.1021/acs.biochem.8b01323. [Epub ahead of print]

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Lin CC, Bachmann M, Bachler S, Venkatesan K, Dittrich PS. Tunable Membrane Potential Reconstituted in Giant Vesicles Promotes Permeation of Cationic Peptides at Nanomolar Concentrations. ACS Appl Mater Interfaces. 2018 Nov 19. doi: 10.1021/acsami.8b12217. [Epub ahead of print].

PubMed ID: 30450894

Kawanabe A, Hashimoto M, Nishizawa M, Nishizawa K, Narita H, Yonezawa T, Jinno Y, Sakata S, Nakagawa A, Okamura Y. The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase. Elife. 2018 Nov 28;7. pii: e41653. doi: 10.7554/eLife.41653.

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Thomas LL, van der Vegt SA, Fromme JC. A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF. Dev Cell. 2019 Jan 7;48(1):100-114.e9. doi: 10.1016/j.devcel.2018.11.013. Epub 2018 Dec 6.

PubMed ID: 30528786

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.

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Nyholm TKM, Jaikishan S, Engberg O, Hautala V, Slotte JP. The Affinity of Sterols for Different Phospholipid Classes and Its Impact on Lateral Segregation. Biophys J. 2019 Jan 22;116(2):296-307. doi: 10.1016/j.bpj.2018.11.3135. Epub 2018 Dec 6.

PubMed ID: 30583790

Drechsler C, Markones M, Choi JY, Frieling N, Fiedler S, Voelker DR, Schubert R, Heerklotz H. Preparation of Asymmetric Liposomes Using a Phosphatidylserine Decarboxylase. Biophys J. 2018 Oct 16;115(8):1509-1517. doi: 10.1016/j.bpj.2018.08.036. Epub 2018 Sep 1.

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Zong W, Thingholm B, Itel F, Schattling PS, Brodszkij E, Mayer D, Stenger S, Goldie KN, Han X, Städler B. Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability. Langmuir. 2018 Jun 1. doi: 10.1021/acs.langmuir.8b01073. [Epub ahead of print]

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What Is the Preferred Conformation of Phosphatidylserine–Copper(II) Complexes? A Combined Theoretical and Experimental Investigation Kari Kusler, Samuel O. Odoh, Alexey Silakov, Matthew F. Poyton, Saranya Pullanchery, Paul S. Cremer and Laura Gagliardi J. Phys. Chem. B, Article ASAP DOI: 10.1021/acs.jpcb.6b10675

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Leventis, P.A., Grinstein, S. (2010) The distribution and function of phosphatidylserine in cellular membranes. Annu Rev Biophys. 39:407-27. Review.

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Saba Ghazvini, Ryan Alonso, Nabil Alhakamy, and Prajnaparamita Dhar. pH induced changes in the surface viscosity of unsaturated phospholipids monitored using active interfacial microrheology. Langmuir, Just Accepted Manuscript

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Maria J. Sarmento, Ana Coutinho, Aleksander Fedorov, Manuel Prieto, and Fabio Fernandes. Membrane Order Is a Key Regulator of Divalent Cation-Induced Clustering of PI(3,5)P2 and PI(4,5)P2. Langmuir. Article ASAP. [PubMed]

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Li G, Kim J, Huang Z, St Clair JR, Brown DA, London E. Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14025-14030. Epub 2016 Nov 21

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