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840032 | Brain PS

L-α-phosphatidylserine (Brain, Porcine) (sodium salt)

Brain PS

Chloroform

Size SKU Packaging Price
10mg 840032C-10mg 840032C-10mg 1 x 10mg 10mg/mL 1mL $162.50
25mg 840032C-25mg 840032C-25mg 1 x 25mg 10mg/mL 2.5mL $244.00
100mg 840032C-100mg 840032C-100mg 1 x 100mg 25mg/mL 4mL $737.00
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Powder

Size SKU Packaging Price
10mg 840032P-10mg 840032P-10mg 1 x 10mg $162.50 162.5
25mg 840032P-25mg 840032P-25mg 1 x 25mg $244.00 244
100mg 840032P-100mg 840032P-100mg 1 x 100mg $737.00 737
500mg 840032P-500mg 840032P-500mg 5 x 100mg $2,435.00 2435
Request Bulk Pricing
Info

Brain PS

L-α-phosphatidylserine (Brain, Porcine) (sodium salt)

Data
Hygroscopic
Yes
Light Sensitive
Yes
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
383907-32-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
824.966
Synonyms
cephalin
Solubility in Different Solvents
Insoluble in ethanol; insoluble in DMSO, Soluble at >5mg/mL in Chloroform:Methanol:Water (65:25:4)
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References

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Garrido CM, Henkels KM, Rehl KM, Liang H, Zhou Y, Gutterman JU, Cho KJ. Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling. Sci Rep. 2020 Jun 4;10(1):9120. doi: 10.1038/s41598-020-65882-5. PMID: 32499517; PMCID: PMC7272413.

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Varela-Chavez C, Blondel A, Popoff MR. Bacterial intracellularly active toxins: Membrane localisation of the active domain. Cell Microbiol. 2020 Jul;22(7):e13213. doi: 10.1111/cmi.13213. Epub 2020 May 28. PMID: 32353188.

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van 't Klooster JS, Cheng TY, Sikkema HR, Jeucken A, Moody B, Poolman B. Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins. Elife. 2020 Apr 17;9:e57003. doi: 10.7554/eLife.57003. PMID: 32301705; PMCID: PMC7182430.

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van Aalst E, Yekefallah M, Mehta AK, Eason I, Wylie B. Codon Harmonization of a Kir3.1-KirBac1.3 Chimera for Structural Study Optimization. Biomolecules. 2020 Mar 10;10(3):E430. doi: 10.3390/biom10030430. PMID: 32164257.

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Tsuboi T, Lu R, Yonezawa T, Watanabe A, Woo JT, Abe-Dohmae S, Yokoyama S. Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 2020 Feb 6;297:32-39. doi: 10.1016/j.atherosclerosis.2020.01.024. Epub ahead of print. PMID: 32062137.

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Träger J, Widder K, Kerth A, Harauz G, Hinderberger D. Effect of Cholesterol and Myelin Basic Protein (MBP) Content on Lipid Monolayers Mimicking the Cytoplasmic Membrane of Myelin. Cells. 2020 Feb 25;9(3):E529. doi: 10.3390/cells9030529. PMID: 32106542.

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Hussain MT, Forbes N, Perrie Y, Malik KP, Duru C, Matejtschuk P. Freeze-drying cycle optimization for the rapid preservation of protein-loaded liposomal formulations. Int J Pharm. 2020 Jan 5;573:118722. doi: 10.1016/j.ijpharm.2019.118722. Epub 2019 Nov 6. PMID: 31705976.

 PubMed ID: 31705976

Dornan GL, Stariha JTB, Rathinaswamy MK, Powell CJ, Boulanger MJ, Burke JE. Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases. Structure. 2019 Nov 29;S0969-2126(19)30397-1. doi: 10.1016/j.str.2019.11.013. [Epub ahead of print]. PMID: 31831213.

 PubMed ID: 31831213

Przeradzka MA, Freato N, Boon-Spijker M, van Galen J, van der Zwaan C, Mertens K, van den Biggelaar M, Meijer AB. Unique surface-exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and von Willebrand factor binding. J Thromb Haemost. 2019 Nov 1. doi: 10.1111/jth.14668. [Epub ahead of print]

 PubMed ID: 31675465

Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N. Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin. Biochim Biophys Acta Biomembr. 2019 Sep 12:183064. doi: 10.1016/j.bbamem.2019.183064. [Epub ahead of print]

 PubMed ID: 31521630

Dingwell DA, Brown LS, Ladizhansky V. Structure of the Functionally Important Extracellular Loop C of Human Aquaporin 1 Obtained by Solid-State NMR under Nearly Physiological Conditions. J Phys Chem B. 2019 Sep 12;123(36):7700-7710. doi: 10.1021/acs.jpcb.9b06430. Epub 2019 Aug 27.

 PubMed ID: 31411472

Ghio S, Camilleri A, Caruana M, Ruf VC, Schmidt F, Leonov A, Ryazanov S, Griesinger C, Cauchi RJ, Kamp F, Giese A, Vassallo N. Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes. ACS Chem Neurosci. 2019 Aug 21;10(8):3815-3829. doi: 10.1021/acschemneuro.9b00320. Epub 2019 Aug 6.

 PubMed ID: 31356747

Jiang J, Hoagland D, Palatinus JA, He H, Iyyathurai J, Jourdan LJ, Bultynck G, Wang Z, Zhang Z, Schey K, Poelzing S, McGowan FX, Gourdie RG. Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury. J Am Heart Assoc. 2019 Aug 20;8(16):e012385. doi: 10.1161/JAHA.119.012385. Epub 2019 Aug 19.

 PubMed ID: 31422747

Chin S, Ramjeesingh M, Hung M, Ereño-Oreba J, Cui H, Laselva O, Julien JP, Bear CE. Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Cells. 2019 Jul 31;8(8). pii: E804. doi: 10.3390/cells8080804.

 PubMed ID: 31370288

Baker KS, Kopec AK, Pant A, Poole LG, Cline-Fedewa H, Ivkovich D, Olyaee M, Woolbright BL, Miszta A, Jaeschke H, Wolberg AS, Luyendyk JP. Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2038-2048. doi: 10.1161/ATVBAHA.119.313215. Epub 2019 Aug 15.

 PubMed ID: 31412737

Bae DJ, Seo J, Kim SY, Park SY, Do Yoo J, Pyo JH, Cho W, Cho JY, Kim S, Kim IS. ArhGAP12 plays dual roles in Stabilin-2 mediated efferocytosis: Regulates Rac1 basal activity and spatiotemporally turns off the Rac1 to orchestrate phagosome maturation. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1595-1607. doi: 10.1016/j.bbamcr.2019.07.003. Epub 2019 Jul 10.

 PubMed ID: 31301364

Mahajan D, Tie HC, Chen B, Lu L. Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking. Nat Commun. 2019 Jul 19;10(1):3218. doi: 10.1038/s41467-019-11056-5.

 PubMed ID: 31324769

Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW, Yan N. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature. 2019 Jul 5. doi: 10.1038/s41586-019-1377-y. [Epub ahead of print]

 PubMed ID: 31278385

Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, Kim WY, Earp HS, Liu P. MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Nat Commun. 2019 Apr 3;10(1):1515. doi: 10.1038/s41467-019-09233-7.

 PubMed ID: 30944303

Nandigama K, Lusvarghi S, Shukla S, Ambudkar SV. Large-scale purification of functional human P-glycoprotein (ABCB1). Protein Expr Purif. 2019 Jul;159:60-68. doi: 10.1016/j.pep.2019.03.002. Epub 2019 Mar 6.

 PubMed ID: 30851394

Jamecna D, Polidori J, Mesmin B, Dezi M, Levy D, Bigay J, Antonny B. An Intrinsically Disordered Region in OSBP Acts as an Entropic Barrier to Control Protein Dynamics and Orientation at Membrane Contact Sites. Dev Cell. 2019 Mar 16. pii: S1534-5807(19)30144-3. doi: 10.1016/j.devcel.2019.02.021. [Epub ahead of print]

 PubMed ID: 30905771

Dahlbäck B, Guo LJ, Zöller B, Tran S. New functional test for the TFPIα cofactor activity of Protein S working in synergy with FV-Short. J Thromb Haemost. 2019 Apr;17(4):585-595. doi: 10.1111/jth.14405. Epub 2019 Mar 11.

 PubMed ID: 30740865

Takase H, Tanaka M, Nakamura Y, Morita SY, Yamada T, Mukai T. Effects of lipid composition on the structural properties of human serum amyloid A in reconstituted high-density lipoprotein particles. Chem Phys Lipids. 2019 Mar 2;221:8-14. doi: 10.1016/j.chemphyslip.2019.03.001. [Epub ahead of print]

 PubMed ID: 30836067

Koponen A, Arora A, Takahashi K, Kentala H, Kivelä AM, Jääskeläinen E, Peränen J, Somerharju P, Ikonen E, Viitala T, Olkkonen VM. ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol. Biochimie. 2019 Mar;158:90-101. doi: 10.1016/j.biochi.2018.12.013. Epub 2018 Dec 24.

 PubMed ID: 30590084

You DG, Cho YY, Lee HR, Lee JH, Yu SJ, Yoon JH, Yoo YD, Kim YJ, Lee GY. Hepatitis B virus X protein induces size-selective membrane permeabilization through interaction with cardiolipin. Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):729-737. doi: 10.1016/j.bbamem.2019.01.006. Epub 2019 Jan 16.

PubMed ID: 30658058

Witkos TM, Chan WL, Joensuu M, Rhiel M, Pallister E, Thomas-Oates J, Mould AP, Mironov AA, Biot C, Guerardel Y, Morelle W, Ungar D, Wieland FT, Jokitalo E, Tassabehji M, Kornak U, Lowe M. GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation. Nat Commun. 2019 Jan 10;10(1):127. doi: 10.1038/s41467-018-08044-6.

 PubMed ID: 30631079

Forbes N, Hussain MT, Briuglia ML, Edwards DP, Horst JHT, Szita N, Perrie Y. Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring. Int J Pharm. 2019 Feb 10;556:68-81. doi: 10.1016/j.ijpharm.2018.11.060. Epub 2018 Nov 29.

 PubMed ID: 30503269

Widder K, Träger J, Kerth A, Harauz G, Hinderberger D. Interaction of myelin basic protein with myelin-like lipid monolayers at the air-water interface. Langmuir. 2018 May 3. doi: 10.1021/acs.langmuir.8b00321.

 PubMed ID: 29722987

Metabolomics and lipidomics using traveling-wave ion mobility mass spectrometry, Giuseppe Paglia & Giuseppe Astarita Nature Protocols 12, 797-813 (2017) doi:10. 1038/nprot.2017.013 [PubMed]

 PubMed ID: 28301461
Fatty Acid Distribution

This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

840032FattyAcidDistribution.gif
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