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810281 | TopFluor™ PC

1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phosphocholine

TopFluor™ PC

Powder

Size SKU Packaging Price
1mg 810281P-1mg 810281P-1mg 1 x 1mg $281.67
5mg 810281P-5mg 810281P-5mg 5 x 1mg $450.15
10mg 810281P-10mg 810281P-10mg 5 x 2mg $640.40
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Chloroform

Size SKU Packaging Price
1mg 810281C-1mg 810281C-1mg 1 x 1mg 1mg/mL 1mL $281.67 281.67
5mg 810281C-5mg 810281C-5mg 5 x 1mg 1mg/mL 1mL $450.15 450.15
10mg 810281C-10mg 810281C-10mg 5 x 2mg 1mg/mL 2mL $640.40 640.4
Request Bulk Pricing
Info

TopFluor™ PC

1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phosphocholine

TopFluor™ PC, or 1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phosphocholine, is a specialized phospholipid with a fluorescence label that is used extensively in cell membrane studies and fluorescence microscopy. Phosphatidylcholines (PC) are the building blocks of eukaryotic membranes and are an important component of the colon's mucosal layer. As such, PC is a strong bilayer-forming lipid.

The TopFluor™ label is a green fluorescent probe attached to the phospholipid molecule that allows researchers to visualize and track the behavior of lipids in biological systems.

Application

TopFluor™ PC shows promise in various experimental applications relating to fluorescent studies. It has been effectively used in the formation of small unilamellar vesicles, providing a reliable model for studying membrane biophysics.

It's also been utilized in the preparation of unilamellar phospholipid liposomes. These liposomes are essential for investigating lipid-protein interactions and drug delivery systems.

Additionally, its fluorescent properties make it an excellent choice for tracking lipid movement and distribution within cells to help develop targeted therapeutic strategies.

Furthermore, phosphatidylcholine functions as a surfactant in the mucosal layer by creating a hydrophobic surface that inhibit bacterial penetrance and infection. This makes TopFluor™ PC a valuable asset in research focused on understanding and enhancing mucosal barrier functions. It can also be used to treat fat embolism, giving it a significant role in medical applications, as well.

Packaging

TopFluor™ PC is available in powder and chloroform solution forms in 1 mg, 5 mg, and 10 mg packaging (pkg), giving you flexibility in your different research requirements.

Avanti’s TopFluor™ PC is distinguished by its superior quality (>99% purity) and rigorous testing. Avanti Research supports researchers with expert guidance on product application to maximize your research outcomes.


Data
Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C48H83BF2N3O8P
Percent Composition
C 63.36%, H 9.19%, B 1.19%, F 4.18%, N 4.62%, O 14.07%, P 3.40%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1246355-63-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
909.969
Exact Mass
909.598
Synonyms
1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phosphocholine
Ex/Em
495/503nm
Downloads
References

Ferrer JR, Sinegra AJ, Ivancic D, Yeap XY, Qiu L, Wang JJ, Zhang ZJ, Wertheim JA, Mirkin CA. Structure-Dependent Biodistribution of Liposomal Spherical Nucleic Acids. ACS Nano. 2020 Jan 17:10.1021/acsnano.9b07254. doi: 10.1021/acsnano.9b07254. Epub ahead of print. PMID: 31951368.

 PubMed ID: 31951368

Regan D, Williams J, Borri P, Langbein W. Lipid Bilayer Thickness Measured by Quantitative DIC Reveals Phase Transitions and Effects of Substrate Hydrophilicity. Langmuir. 2019 Oct 29;35(43):13805-13814. doi: 10.1021/acs.langmuir.9b02538. Epub 2019 Oct 14.

 PubMed ID: 31483674

Baxter AM, Wittenberg NJ. Excitation of Fluorescent Lipid Probes Accelerates Supported Lipid Bilayer Formation via Photosensitized Lipid Oxidation. Langmuir. 2019 Sep 3;35(35):11542-11549. doi: 10.1021/acs.langmuir.9b01535. Epub 2019 Aug 22.

 PubMed ID: 31411482

Girish V, Pazzi J, Li A, Subramaniam AB. Fabrics of Diverse Chemistries Promote the Formation of Giant Vesicles from Phospholipids and Amphiphilic Block Copolymers. Langmuir. 2019 Jul 16;35(28):9264-9273. doi: 10.1021/acs.langmuir.9b01621. Epub 2019 Jul 5.

 PubMed ID: 31276413

Baxter A, Wittenberg NJ. Excitation of Fluorescent Lipid Probes Accelerates Supported Lipid Bilayer Formation via Photosensitized Lipid Oxidation. Langmuir. 2019 Aug 14. doi: 10.1021/acs.langmuir.9b01535. [Epub ahead of print]

 PubMed ID: 31411482

Wu D, Jin X, Wang X, Ma B, Lou C, Qu H, Zheng J, Zhang B, Yan X, Wang Y, Jing L. Engineering temperature-sensitive plateletsomes as a tailored chemotherapy platform in combination with HIFU ablation for cancer treatment. Theranostics. 2019 May 31;9(13):3966-3979. doi: 10.7150/thno.32172. eCollection 2019.

 PubMed ID: 31281525

Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D. Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. ACS Nano. 2019 Jun 18. doi: 10.1021/acsnano.9b00686. [Epub ahead of print]

 PubMed ID: 31194909

Iachina I, Antonescu IE, Dreier J, Sørensen JA, Brewer JR. The nanoscopic molecular pathway through human skin. Biochim Biophys Acta Gen Subj. 2019 Jul;1863(7):1226-1233. doi: 10.1016/j.bbagen.2019.04.012. Epub 2019 Apr 15.

 PubMed ID: 30998962

Marcos-Contreras OA, Brenner JS, Kiseleva RY, Zuluaga-Ramirez V, Greineder CF, Villa CH, Hood ED, Myerson JW, Muro S, Persidsky Y, Muzykantov VR. Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain. J Control Release. 2019 Mar 11;301:54-61. doi: 10.1016/j.jconrel.2019.03.008. [Epub ahead of print]

 PubMed ID: 30871995

Jurek I, Góral I, Mierzyńska Z, Moniuszko-Szajwaj B, Wojciechowski K. Effect of synthetic surfactants and soapwort (Saponaria officinalis L.) extract on skin-mimetic model lipid monolayers. Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):556-564. doi: 10.1016/j.bbamem.2018.12.005. Epub 2018 Dec 21.

 PubMed ID: 30579962

Pazzi J, Xu M, Subramaniam AB. Size Distributions and Yields of Giant Vesicles Assembled on Cellulose Papers and Cotton Fabric. Langmuir. 2018 Nov 16. doi: 10.1021/acs.langmuir.8b03076. [Epub ahead of print].

 PubMed ID: 30444125

Sæle Ø, Rød KEL, Quinlivan VH, Li S, Farber SA. A novel system to quantify intestinal lipid digestion and transport. Biochim Biophys Acta. 2018 May 17. pii: S1388-1981(18)30098-2. doi: 10.1016/j.bbalip.2018.05.006.

 PubMed ID: 29778665

Kay, J.G., M. Koivusalo, X. Ma, T. Wohland, and S. Grinstein. (2012). Phosphatidylserine dynamics in cellular membranes. Mol Biol Cell 23:2198-212.

 PubMed ID: 22496416

Disordering Effects of Digitonin on Phospholipid Monolayers M. Orczyk, K. Wojciechowski , and G. Brezesinski Langmuir, Article ASAP

PubMed ID: 28333465
Spectrum
TopFluorEmEx4of.gif
Certificates of Analysis

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