810255 | TopFluor™ Cholesterol
23-(dipyrrometheneboron difluoride)-24-norcholesterol

TopFluor™ Cholesterol
23-(dipyrrometheneboron difluoride)-24-norcholesterol
CAS Registry Number is a Registered Trademark of the American Chemical Society
Bdp-Chol
Bernecic NC, Gadella BM, de Graaf SP, Leahy T. Synergism between albumin, bicarbonate and cAMP upregulation for cholesterol efflux from ram sperm. Reproduction. 2020 Aug;160(2):269-280. doi: 10.1530/REP-19-0430. PMID: 32460237.
PubMed ID: 32460237Carro MLM, Peñalva DA, Antollini SS, Hozbor FA, Buschiazzo J. Cholesterol and desmosterol incorporation into ram sperm membrane before cryopreservation: Effects on membrane biophysical properties and sperm quality. Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183357. doi: 10.1016/j.bbamem.2020.183357. Epub 2020 May 13. PMID: 32416195.
PubMed ID: 32416195Sibold J, Tewaag VE, Vagedes T, Mey I, Steinem C. Phase separation in pore-spanning membranes induced by differences in surface adhesion. Phys Chem Chem Phys. 2020 May 6;22(17):9308-9315. doi: 10.1039/d0cp00335b. PMID: 32309836.
PubMed ID: 32309836Lee HR, You DG, Kim HK, Sohn JW, Kim MJ, Park JK, Lee GY, Yoo YD. Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis. mBio. 2020 Apr 14;11(2):e03258-19. doi: 10.1128/mBio.03258-19. PMID: 32291307; PMCID: PMC7157825.
PubMed ID: 32291307Navdaev AV, Sborgi L, Wright SD, Didichenko SA. Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres: Effects of HDL Particle Remodeling on Cholesterol Efflux. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1182-1194. doi: 10.1161/ATVBAHA.120.313906. Epub 2020 Mar 5. PMID: 32131613.
PubMed ID: 32131613Lin M, Grandinetti G, Hartnell LM, Bliss D, Subramaniam S, Rikihisa Y. Host membrane lipids are trafficked to membranes of intravacuolar bacterium Ehrlichia chaffeensis. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8032-8043. doi: 10.1073/pnas.1921619117. Epub 2020 Mar 19. PMID: 32193339; PMCID: PMC7149431.
PubMed ID: 32193339Hayakawa EH, Yamaguchi K, Mori M, Nardone G. Real-time cholesterol sorting in Plasmodium falciparum-erythrocytes as revealed by 3D label-free imaging. Sci Rep. 2020 Feb 17;10(1):2794. doi: 10.1038/s41598-020-59552-9. PMID: 32066816; PMCID: PMC7026401.
PubMed ID: 32066816Lee HR, Lee GY, You DG, Kim HK, Yoo YD. Hepatitis C Virus p7 Induces Membrane Permeabilization by Interacting with Phosphatidylserine. Int J Mol Sci. 2020 Jan 30;21(3):897. doi: 10.3390/ijms21030897. PMID: 32019133; PMCID: PMC7037181.
PubMed ID: 32019133Sánchez-Pérez H, Quevedo-Abeledo JC, de Armas-Rillo L, Rua-Figueroa Í, Tejera-Segura B, Armas-González E, Machado JD, García-Dopico JA, Jimenez-Sosa A, Rodríguez-Lozano C, Díaz-González F, González-Gay MA, Ferraz-Amaro I. Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis. Rheumatology (Oxford). 2020 Feb 17:keaa038. doi: 10.1093/rheumatology/keaa038. Epub ahead of print. PMID: 32065639.
PubMed ID: 32065639Plewes MR, Hou X, Talbott HA, Zhang P, Wood JR, Cupp AS, Davis JS. Luteinizing hormone regulates the phosphorylation and localization of the mitochondrial effector dynamin-related protein-1 (DRP1) and steroidogenesis in the bovine corpus luteum. FASEB J. 2020 Feb 20. doi: 10.1096/fj.201902958R. Epub ahead of print. PMID: 32077149.
PubMed ID: 32077149Ferraz-Amaro I, Hernández-Hernández MV, Armas-González E, Sánchez-Pérez H, Machado JD, Díaz-González F. HDL cholesterol efflux capacity is related to disease activity in psoriatic arthritis patients. Clin Rheumatol. 2020 Jan 28:10.1007/s10067-020-04961-4. doi: 10.1007/s10067-020-04961-4. Epub ahead of print. PMID: 31993889.
PubMed ID: 31993889Yamashita K, Ito K, Endo J, Matsuhashi T, Katsumata Y, Yamamoto T, Shirakawa K, Isobe S, Kataoka M, Yoshida N, Goto S, Moriyama H, Kitakata H, Mitani F, Fukuda K, Goda N, Ichihara A, Sano M. Adrenal cortex hypoxia modulates aldosterone production in heart failure. Biochem Biophys Res Commun. 2020 Jan 23:S0006-291X(20)30157-1. doi: 10.1016/j.bbrc.2020.01.088. Epub ahead of print. PMID: 31982132.
PubMed ID: 31982132Oshita T, Toh R, Nagano Y, Kuroda K, Nagasawa Y, Harada A, Murakami K, Kiriyama M, Yoshikawa K, Miwa K, Kubo T, Iino T, Nagao M, Irino Y, Hara T, Shinohara M, Otake H, Shinke T, Nakajima K, Ishida T, Hirata KI. Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study. Clin Chim Acta. 2020 Jan 21;503:136-144. doi: 10.1016/j.cca.2020.01.001. Epub ahead of print. PMID: 31972150.
PubMed ID: 31972150Ruwisch J, Sehlmeyer K, Roldan N, Garcia-Alvarez B, Perez-Gil J, Weaver TE, Ochs M, Knudsen L, Lopez-Rodriguez E. Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C. Am J Respir Cell Mol Biol. 2020 Jan 10:10.1165/rcmb.2019-0358OC. doi: 10.1165/rcmb.2019-0358OC. Epub ahead of print. PMID: 31922895.
PubMed ID: 31922895Kim HY, Cheon JH, Lee SH, Min JY, Back SY, Song JG, Kim DH, Lim SJ, Han HK. Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization. J Nanobiotechnology. 2020 Jan 21;18(1):17. doi: 10.1186/s12951-020-0579-7. PMID: 31964393; PMCID: PMC6975051.
PubMed ID: 31964393Soria-Florido MT, Castañer O, Lassale C, Estruch R, Salas-Salvadó J, Martínez-González MÁ, Corella D, Ros E, Arós F, Elosua R, Lapetra J, Fiol M, Alonso-Gómez A, Gómez-Gracia E, Serra-Majem L, Pintó X, Bulló M, Ruiz-Canela M, Sorlí JV, Hernáez Á, Fitó M. Dysfunctional HDLs are Associated with a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested-Case Control Study. Circulation. 2020 Jan 16:10.1161/CIRCULATIONAHA.119.041658. doi: 10.1161/CIRCULATIONAHA.119.041658. Epub ahead of print. PMID: 31941372.
PubMed ID: 31941372Feng M, Darabi M, Tubeuf E, Canicio A, Lhomme M, Frisdal E, Lanfranchi-Lebreton S, Matheron L, Rached F, Ponnaiah M, Serrano CV Jr, Santos RD, Brites F, Bolbach G, Gautier E, Huby T, Carrie A, Bruckert E, Guerin M, Couvert P, Giral P, Lesnik P, Le Goff W, Guillas I, Kontush A. Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease. Eur J Prev Cardiol. 2019 Dec 15;2047487319894114. doi: 10.1177/2047487319894114. [Epub ahead of print]. PMID: 31840535.
PubMed ID: 31840535Khattib A, Atrahimovich D, Dahli L, Vaya J, Khatib S. Lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS) isolated from Nannochloropsis microalgae improves high-density lipoprotein (HDL) functions. Biofactors. 2019 Oct 29. doi: 10.1002/biof.1580. [Epub ahead of print]
PubMed ID: 31660677Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23.
PubMed ID: 31548609Reinholdt P, Wind S, Wüstner D, Kongsted J. Computational Characterization of a Cholesterol-Based Molecular Rotor in Lipid Membranes. J Phys Chem B. 2019 Aug 29;123(34):7313-7326. doi: 10.1021/acs.jpcb.9b04967. Epub 2019 Aug 19.
PubMed ID: 31381343Bernecic NC, Zhang M, Gadella BM, Brouwers JFHM, Jansen JWA, Arkesteijn GJA, de Graaf SP, Leahy T. BODIPY-cholesterol can be reliably used to monitor cholesterol efflux from capacitating mammalian spermatozoa. Sci Rep. 2019 Jul 8;9(1):9804. doi: 10.1038/s41598-019-45831-7.
PubMed ID: 31285440Doll F, Keckeis P, Scheel P, Cölfen H. Visualizing Cholesterol Uptake by Self-Assembling Rhodamine B-Labeled Polymer Inside Living Cells via FLIM-FRET Microscopy. Macromol Biosci. 2019 Jun 21:e1900081. doi: 10.1002/mabi.201900081. [Epub ahead of print]
PubMed ID: 31222918Marques PE, Nyegaard S, Collins RF, Troise F, Freeman SA, Trimble WS, Grinstein S. Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane. Dev Cell. 2019 Jun 4. pii: S1534-5807(19)30424-1. doi: 10.1016/j.devcel.2019.05.026. [Epub ahead of print]
PubMed ID: 31231038Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW, Waldmann H. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15(7):710-720. doi: 10.1038/s41589-019-0307-5. Epub 2019 Jun 20.
PubMed ID: 31222192Králová J, Král V. Fluorescent Probes for Monitoring Cholesterol Trafficking in Cells. Folia Biol (Praha). 2019;65(1):1-10.
PubMed ID: 31171077Zhou Y, Miles JR, Tavori H, Lin M, Khoshbouei H, Borchelt D, Bazick H, Landreth GE, Lee S, Fazio S, Notterpek L. PMP22 regulates cholesterol trafficking and ABCA1-mediated cholesterol efflux. J Neurosci. 2019 May 6. pii: 2942-18. doi: 10.1523/JNEUROSCI.2942-18.2019. [Epub ahead of print]
PubMed ID: 31061090Nagano Y, Otake H, Toba T, Kuroda K, Shinkura Y, Tahara N, Tsukiyama Y, Yanaka K, Yamamoto H, Nagasawa A, Onishi H, Sugizaki Y, Takeshige R, Harada A, Murakami K, Kiriyama M, Oshita T, Irino Y, Kawamori H, Ishida T, Toh R, Shinke T, Hirata KI. Impaired Cholesterol-Uptake Capacity of HDL Might Promote Target-Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation. J Am Heart Assoc. 2019 May 7;8(9):e011975. doi: 10.1161/JAHA.119.011975.
PubMed ID: 30995875Stumpf SK, Berghoff SA, Trevisiol A, Spieth L, Düking T, Schneider LV, Schlaphoff L, Dreha-Kulaczewski S, Bley A, Burfeind D, Kusch K, Mitkovski M, Ruhwedel T, Guder P, Röhse H, Denecke J, Gärtner J, Möbius W, Nave KA, Saher G. Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathol. 2019 Mar 27. doi: 10.1007/s00401-019-01985-2. [Epub ahead of print]
PubMed ID: 30919030Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA. Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens. Life Sci Alliance. 2019 Mar 22;2(2). pii: e201800292. doi: 10.26508/lsa.201800292. Print 2019 Apr.
PubMed ID: 30902833Otis JP, Shen MC, Caldwell BA, Reyes Gaido OE, Farber SA. Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G350-G365. doi: 10.1152/ajpgi.00080.2018. Epub 2019 Jan 10.
PubMed ID: 30629468Dergunov AD, Litvinov DY, Bazaeva EV, Dmitrieva VG, Nosova EV, Rozhkova AV, Dergunova LV. Relation of High-Density Lipoprotein Charge Heterogeneity, Cholesterol Efflux Capacity, and the Expression of High-Density Lipoprotein-Related Genes in Mononuclear Cells to the HDL-Cholesterol Level. Lipids. 2018 Oct;53(10):979-991. doi: 10.1002/lipd.12104. Epub 2018 Nov 15.
PubMed ID: 30430582Nyholm TKM, Jaikishan S, Engberg O, Hautala V, Slotte JP. The Affinity of Sterols for Different Phospholipid Classes and Its Impact on Lateral Segregation. Biophys J. 2019 Jan 22;116(2):296-307. doi: 10.1016/j.bpj.2018.11.3135. Epub 2018 Dec 6.
PubMed ID: 30583790Wang M, Liu Z, Zhan W. Janus Liposomes: Gel-Assisted Formation and Bioaffinity-Directed Clustering. Langmuir. 2018 Jun 12. doi: 10.1021/acs.langmuir.8b00798. [Epub ahead of print]
PubMed ID: 29852065Crowley, J.T., A.M. Toledo, T.J. LaRocca, J.L. Coleman, E. London, and J.L. Benach. (2013). Lipid exchange between Borrelia burgdorferi and host cells. PLoS Pathog 9:e1003109
PubMed ID: 23326230Lund, F.W., M.A. Lomholt, L.M. Solanko, R. Bittman, and D. Wustner. (2012). Two-photon time-lapse microscopy of BODIPY-cholesterol reveals anomalous sterol diffusion in chinese hamster ovary cells. BMC Biophys. 2012 Oct 18;5:20. doi: 10.1186/2046-1682-5-20.
PubMed ID: 23078907Littleton, R.M., M. Miller, and J.R. Hove. (2012). Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model. BMC Complement Altern Med. 2012 Jul 23;12:105. doi: 10.1186/1472-6882-12-105.
PubMed ID: 22824306C. Röhrl, C. Meisslitzer-Ruppitsch, R. Bittman, Z. Li, G. Pabst, R. Prassl, W. Strobl, J. Neumüller, A. Ellinger, M. Pavelka, and H. Stangl, “Combined Light and Electron Microscopy using Diaminobenzidine Photooxidation to Monitor Trafficking of Lipids Derived from Lipoprotein Particles,” Curr. Pharm. Biotechnol. 13, 331-340 (2012).
PubMed ID: 21470121S. Sankaranarayanan, G. Kellner-Weibel, M. de la Llera-Moya, M. C. Phillips, B. F. Asztalos, R. Bittman, and G. H. Rothblat, “A Sensitive Assay for ABCA1-Mediated Cholesterol Efflux Using Bodipy-Cholesterol," J. Lipid Res. 52, 2332-2340 (2011).
PubMed ID: 21957199D. Wüstner, L. Solanko, F. W. Lund, O. Garvik, Z. Li, R. Bittman, T. Korte, and A. Herrmann, “Quantitative Assessment of Sterol Traffic in Living Cells by Dual Labeling with Dehydroergosterol and BODIPY-Cholesterol,” Chem. Phys. Lipids 164, 221-235 (2011).
PubMed ID: 21291873S. Scolari, K. Müller, R. Bittman, A. Herrmann, and P. Müller, “Interaction of Mammalian Seminal Plasma Protein PDC-109 with Cholesterol – Implications for a Putative CRAC Domain,” Biochemistry 49, 9027-9031 (2010).
PubMed ID: 20863067K. Trajkovic, C. Hsu, S. Chianti, L. Rajendran, D. Wenzel, F. Wieland, P. Schwille, B. Brügger, and M. Simons, "Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes," Science 319, 1244-1247 (2008).
PubMed ID: 18309083S. Chiantia, J. Ries, G. Chwastek, D. Carrer, Z. Li, R. Bittman, and P. Schwille, “Role of Ceramide in Membrane Protein Organization Investigated by Combined AFM and FCS,” Biochim. Biophys. Acta Biomembranes 1778, 1356-1364 (2008).
PubMed ID: 18346453B. Y. Baker, R. F. Epand, R. M. Epand, and W. L. Miller, "Cholesterol Binding Does Not predict Activity of the Steroidogenic Acute Regulatory Protein, StAR," Biochemistry 282, 10223-10232 (2007).
PubMed ID: 17301050J. E. Shaw, R. F. Epand, K. Sinnathamby, Z. Li, R. Bittman, R. M. Epand, and C. M. Yip, “Tracking Peptide-Membrane Interactions: Insights from in situ Coupled Confocal-Atomic Force Microscopy Imaging of NAP-22 Peptide Insertion and Assembly,” J. Struct. Biol. 155, 458-469 (2006).
PubMed ID: 16889981J. E. Shaw, R. F. Epand, R. M. Epand, Z. Li, R. Bittman, and C. M. Yip, “Correlated Fluorescence-Atomic Force Microscopy of Membrane Domains: Structure of Fluorescence Probes Determines Lipid Localization,” Biophys J. 90, 2170-2178 (2006).
PubMed ID: 16361347Z. Li and R. Bittman, “Synthesis and Spectral Properties of Cholesterol- and FTY720-containing Boron Dipyrromethene Dyes,” J. Org. Chem. 72, 8376-8382 (2007).
PubMed ID: 17914846M. Hölttä-Vuori, R. L. Uronen, J. Repakova, E. Salonen, I. Vattulainen, P. Panula, Z. Li, R. Bittman, and E. Ikonen, “BODIPY-Cholesterol: A New Tool to Visualize Sterol Trafficking in Living Cells and Organisms,” Traffic 9, 1839-1849 (2008).
PubMed ID: 18647169D. L. Marks, R. Bittman, and R. E. Pagano, “Use of Bodipy-labeled Sphingolipid and Cholesterol Analogs to Examine Membrane Microdomains in Cells,” Histochem. Cell Biol. 130, 819-832 (2008).
PubMed ID: 18820942F. S. Ariola, Z. Li, C. Cornejo, R. Bittman, and A. A. Heikal, “Membrane Fluidity and Lipid Order in Ternary Giant Unilamellar Vesicles Using a New Bodipy-Cholesterol Derivative,” Biophys J. 96, 2696-2708 (2009).
PubMed ID: 19348752Z. Li, E. Mintzer, and R. Bittman, “First Synthesis of Free Cholesterol – BODIPY Conjugates,” J. Org. Chem. 71, 1718-1721 (2006).
PubMed ID: 16468832- Certificate of Analysis (Lot No. 810255P-10MG-A-017 and 5407PIA017)
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