810110 | 12-NBD Stearate
12-N-methyl-(7-nitrobenz-2-oxa-1,3-diazo)aminostearic acid
12-NBD Stearate
12-N-methyl-(7-nitrobenz-2-oxa-1,3-diazo)aminostearic acid
NBD-stearate is a fluorescent fatty acid analogue used to probe fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2).
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozBai L, Parkin LA, Zhang H, Shum R, Previti ML, Seeliger JC. Dimethylaminophenyl Hydrazides as Inhibitors of the Lipid Transport Protein LprG in Mycobacteria. ACS Infect Dis. 2020 Mar 3. doi: 10.1021/acsinfecdis.9b00497. Epub ahead of print. PMID: 32053347.
PubMed ID: 32053347Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d'Oelsnitz S, Kaczocha M. FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Sci Rep. 2019 Dec 12;9(1):18944. doi: 10.1038/s41598-019-55418-x. PMID: 31831821; PMCID: PMC6908725.
PubMed ID: 31831821Kim J, Bogdan DM, Elmes MW, Awwa M, Yan S, Che J, Lee G, Deutsch DG, Rizzo RC, Kaczocha M, Ojima I. Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation. PLoS One. 2019 Jun 25;14(6):e0218619. doi: 10.1371/journal.pone.0218619. eCollection 2019.
PubMed ID: 31237895Pohl J, Ring A, Stremmel W. Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res. 2002 Sep;43(9):1390-9. [PubMed]
PubMed ID: 12235170Atshaves BP, Storey SM, McIntosh AL, Petrescu AD, Lyuksyutova OI, Greenberg AS, Schroeder F. Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets. J Biol Chem. 2001 Jul 6;276(27):25324-35. [PubMed]
PubMed ID: 11333258Milliano MT, Luxon BA. The peroxisomal proliferator clofibrate enhances the hepatic cytoplasmic movement of fatty acids in rats. Hepatology. 2001 Feb;33(2):413-8. [PubMed]
PubMed ID: 11172343Murphy EJ. Sterol carrier protein-2 expression increases NBD-stearate uptake and cytoplasmic diffusion in L cells. Am J Physiol. 1998 Aug;275(2 Pt 1):G237-43. [PubMed]
PubMed ID: 9688650Atshaves BP, Foxworth WB, Frolov A, Roths JB, Kier AB, Oetama BK, Piedrahita JA, Schroeder F. Cellular differentiation and I-FABP protein expression modulate fatty acid uptake and diffusion. Am J Physiol. 1998 Mar;274(3 Pt 1):C633-44. [PubMed]
PubMed ID: 9530094Schroeder F, Myers-Payne SC, Billheimer JT, Wood WG. Probing the ligand binding sites of fatty acid and sterol carrier proteins: effects of ethanol. Biochemistry. 1995 Sep 19;34(37):11919-27. [PubMed]
PubMed ID: 7547928Luxon BA. Inhibition of binding to fatty acid binding protein reduces the intracellular transport of fatty acids. Am J Physiol. 1996 Jul;271(1 Pt 1):G113-20. [PubMed]
PubMed ID: 8760114Data was generously provided by Dr. Huan Huang and Dr. Fred Schroeder, Texas A & M University.
Pattern of distribution in living L-cell fibroblasts
| 300nM NBD-Stearate, 15min | 500nM NBD-Stearate, 15min | 20nM Nile Red, 15min |
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Photos courtesy of Dr. Huan Huang and Dr. Fred Schroeder, Texas A & M University.
- Certificate of Analysis (Lot No. 810110C-1MG-A-010 and 5313CGA010)
- Certificate of Analysis (Lot No. 810110P-1MG-A-010 and 5313PGA010)
- Certificate of Analysis (Lot No. 810110P-1MG-B-010 and 5313PGB010)
- Certificate of Analysis (Lot No. 810110P-1MG-C-010 and 5313PGC010)
- Certificate of Analysis (Lot No. 810110P-1MG-D-010 and 5313PGD010)
- Certificate of Analysis (Lot No. 810110P-1MG-F-010 and 5313PGF010)
