Section Menu

800800 | 08:0 DG

Name: 08:0 DG
Brand: Avanti Research
SKU: 800800O-25mg
Price: 120.6 USD
Availability: InStock

1,2-dioctanoyl-sn-glycerol

Oil

	Size	SKU	Packaging	Price
	10mg	800800O-10mg 800800O-10mg	1 x 10mg	$120.60 120.6
	25mg	800800O-25mg 800800O-25mg	1 x 25mg	$213.25 213.25

Request Bulk Pricing

Chloroform

	Size	SKU	Packaging	Price
	10mg	800800C-10mg 800800C-10mg	1 x 10mg 2mg/mL 5mL	$120.60 120.6
	25mg	800800C-25mg 800800C-25mg	1 x 25mg 5mg/mL 5mL	$213.25 213.25

Request Bulk Pricing

Info

08:0 DG

1,2-dioctanoyl-sn-glycerol

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP₂ (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP₃). Although inositol trisphosphate (IP₃) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP₃ stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. (See References)

Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Storage:

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with teflon-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Delivery to cells:

Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:

Most biological responses saturate at 20 to 250 µM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Data

Hygroscopic

Yes

Light Sensitive

Molecular Formula

C₁₉H₃₆O₅

Percent Composition

C 66.25%, H 10.53%, O 23.22%

Purity

<99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

60514-48-9
CAS Registry Number is a Registered Trademark of the American Chemical Society

Formula Weight

344.486

Exact Mass

344.256

Synonyms

Downloads

References

Choudhary V, El Atab O, Mizzon G, Prinz WA, Schneiter R. Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis. J Cell Biol. 2020 Jul 6;219(7):e201910177. doi: 10.1083/jcb.201910177. PMID: 32349126.

PubMed ID: 32349126

Starr ML, Sparks RP, Arango AS, Hurst LR, Zhao Z, Lihan M, Jenkins JL, Tajkhorshid E, Fratti RA. Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming. J Biol Chem. 2019 Mar 1;294(9):3100-3116. doi: 10.1074/jbc.RA118.006552. Epub 2019 Jan 7.

PubMed ID: 30617180

Ebeling, J.G., Vandenbark, G.R., Kuhn, L., Ganong, B., Bell, R.M. & Niedel, J.E. (1985) Diacylglycerols and Phorbol Diesters Induce Leukemic Cell Differentiation via a Common Mechanism. Proc. Natl. Acad. Sci. USA 82:815-819.

Davis, R.J., Ganong, B.R., Bell, R.M. & Czech, M.P. (1985) sn-1,2-dioctanoylglycerol: a Cell Permeable Diacylglycerol That Mimics Phorbol Diester Action on the Epidermal Growth Factor Receptor and Mitogenesis. J. Biol. Chem. 260:1562-1566.

PubMed ID: 2981862

Lapetina, E.G., Reep, B., Ganong, B.R. & Bell, R.M. (1985) Exogenous sn-1,2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets. J. Biol. Chem. 260:1358-1361.

Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M. (1986) Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols. Proc. Natl. Acad. Sci. USA 83:1184-1188.

PubMed ID: 3456578

Cart

Item	Price	Qty.
${ item.sku } Base Price: $${ (item.price - (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150))).toFixed(2) } Custom Packaging: +${ (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150)).toFixed(2) } Change Custom Packaging	${ item.salePriceAsCurrency }

Subtotal: ${ cart.itemSubtotal|money }

${ adjustment.type }: ${ adjustment.name } ${ adjustment.amountAsCurrency }

${ adjustment.name } ${ adjustment.amountAsCurrency }

Order Total: ${ cart.totalPriceAsCurrency }

Have a promo code? Enter it in your cart to apply your discount and enjoy the savings on your purchase! Finalize Cart

800800 | 08:0 DG

1,2-dioctanoyl-sn-glycerol