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792885 | SM-102

heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate

SM-102

Product is provided for Research Use Only intended for seeking Food and Drug Administration’s (FDA) approval under The Hatch-Waxman Act (formally known as the Drug Price Competition and Patent Term Restoration Act of 1984).

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Info

SM-102

heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate

SM-102, a synthetic ionizable lipid with a pKa of 6.68, can be used in combination with other lipids to formulate lipid nanoparticles (LNPs) for drug delivery applications. mRNA delivery via LNPs formulated with SM-102 show good efficiency and accumulation primarily in the liver.

SM-102 is most known as a component of mRNA-based COVID-19 vaccines but has also been, and continues to be, studied for delivery of other payloads and various applications. Below is a sample of studies conducted using formulations containing SM-102:

  • Peptide-conjugated PLK1-targeted siRNA delivery across the blood-brain barrier for treatment of glioblastoma multiforme.1
  • Transfection of dendritic cells with circular RNA (circRNA) vaccines to elicit T cell responses.2
  • Delivery of ribonucleoproteins (RNPs) for in vivo genome editing.3

References:

  1. Haiyang Tong, Zesen Ma, Jin Yu, Dongsheng Li, Qingjun Zhu, Huajian Shi, Yun Wu, Hongyi Yang, Yanmin Zheng, Demeng Sun, Pan Shi, Jiaru Chu, Pei Lv, Baoqing Li, and Changlin Tian. ACS Chemical Biology 2025 20 (4), 942-952. DOI: 10.1021/acschembio.5c00039
  2. Yasir Alshehry, Xiang Liu, Yu Zhang, Guizhi Zhu. Journal of Controlled Release 2025 381. DOI: 10.1016/j.jconrel.2025.113617
  3. Hołubowicz, R., Du, S.W., Felgner, J. et al. Nat. Biomed. Eng 9, 57–78 (2025). DOI: 10.1038/s41551-024-01296-2
Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C44H87NO5
Percent Composition
C 74.42%, H 12.35%, N 1.97%, O 11.26%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
2089251-47-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
710.18
Exact Mass
709.66
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