700244 | Tauro-ß-muricholic acid, sodium salt
5ß-cholanic acid-3α,6ß,7ß-triol N-(2-sulphoethyl)-amide, sodium salt
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Tauro-ß-muricholic acid, sodium salt
5ß-cholanic acid-3α,6ß,7ß-triol N-(2-sulphoethyl)-amide, sodium salt
Tauro-β-Muricholic Acid is an endogenous steroid metabolite, released from the liver in human and rat organisms.
The compound is derived from the bile acid (BA) β-muricholic acid through an enzyme-regulated process of conjugation between the BA and the amino acid taurine. β-Muricholic acid is a member of the group of muricholic acids and its hydroxy groups at positions 6 and 7 have β-configuration.
Tauro-β-Muricholic Acid is most commonly used as an experimental metabolite in cholestasis research.
The compound, together with other taurine-conjugated forms of muricholic acids, is also believed to be a reversible and competitive antagonist of the Farnesoid X receptor (FXR).
Farnesoid X receptor belongs to the superfamily of nuclear receptors and has an important role as a molecule that contributes to the physiological occurrence of different metabolic reactions. It’s related to BA metabolism and homeostasis and is activated by BAs at the same time.
Hence, Tauro-β-Muricholic Acid can be implied as a detergent in experimental work concerning FXR properties and potential effects in the treatment of certain conditions.
The taurine conjugate is also considered to increase concentrations of serum cytokines, including IL-6, IL-17, and IFN-γ.
Rely on Avanti Research to provide you with a highly pure and stable Tauro-β-Muricholic Acid research product for quality experimental development.
C26H44NNaO7S
C 58.08%, H 8.25%, N 2.61%, Na 4.28%, O 20.83%, S 5.96%
CAS Registry Number is a Registered Trademark of the American Chemical Society
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- Certificate of Analysis (Lot No. 700244P-1MG-B-010 and 6871PGB010)
- Certificate of Analysis (Lot No. 700244P-1MG-C-010 and 6871PGC010)
- Certificate of Analysis (Lot No. 700244P-1MG-D-010 and 6871PGD010)
- Certificate of Analysis (Lot No. 700244P-1MG-E-010 and 6871PGE010)
- Certificate of Analysis (Lot No. 700244P-1MG-F-010 and 6871PGF010)
- Certificate of Analysis (Lot No. 700244P-1MG-G-010 and 6871PGG010)
