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700147 | PhotoClick Cholesterol

Hex-5'-ynyl 3ß-hydroxy-6-diazirinyl-5α-cholan-24-oate

PhotoClick Cholesterol

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Size SKU Packaging Price
100µg 700147P-100ug 700147P-100ug $261.00
250µg 700147P-250ug 700147P-250ug $552.50
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Info

PhotoClick Cholesterol

Hex-5'-ynyl 3ß-hydroxy-6-diazirinyl-5α-cholan-24-oate

PhotoClick Cholesterol is a clickable, photoreactive sterol probe for use in combination with quantitative mass spectrometry to globally map cholesterol-protein interactions directly in living cells. In addition to the UV-activatable cross-linking diazirine group that reacts with proteins, the sterol contains an alkyne group for incorporation of reporter and affinity tags through click-chemistry.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C30H46N2O3
Percent Composition
C 74.65%, H 9.61%, N 5.80%, O 9.94%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1485490-47-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
482.698
Exact Mass
482.351
Synonyms
hex-5-yn-1-yl 4-((3S,5S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,7,8,9,10,11,12,13,14,15,16,17 hexadecahydrospiro[cyclopenta[a]phenanthrene-6,3'-diazirin]-17-yl)pentanoate
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References

Chauhan N, Sere YY, Sokol AM, Graumann J, Menon AK. A PhotoClick cholesterol-based quantitative proteomics screen for cytoplasmic sterol binding proteins in Saccharomyces cerevisiae. Yeast. 2019 Nov 22. doi: 10.1002/yea.3448. [Epub ahead of print]

 PubMed ID: 31758572

Hulce JJ, Cognetta AB, Niphakis MJ, Tully SE, Cravatt BF. Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nat Methods. 2013 Mar;10(3):259-64. doi: 10.1038/nmeth.2368. Epub 2013 Feb 10. PMID: 23396283; PMCID: PMC3601559.

 PubMed ID: 23396283
Certificates of Analysis

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