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700100 | cholesterol (plant)

cholesterol (plant)

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Size SKU Packaging Price
100mg 700100P-100mg 700100P-100mg 1 x 100mg $253.00
200mg 700100P-200mg 700100P-200mg 1 x 200mg $432.00
500mg 700100P-500mg 700100P-500mg 1 x 500mg $920.00
1g 700100P-1g 700100P-1g 1 x 1g $1,646.57
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Info

cholesterol (plant)

Cholesterol (plant-derived) is a minor plant sterol found in plant cells and a component of surface lipids. It is vital to plant metabolism and indicates the creation of various bioactive plant metabolites. Approximately 25 percent of the brain's lipid content is cholesterol, making it a major component of not just cell plasma membranes but all biological membranes.

Applications

As a structural component in biological membranes, cholesterol is essential to cell biology, membrane dynamics, and lipid metabolism studies. It has a significant effect on membrane integrity, fluidity, and signaling processes.

Cholesterol (plant derived) shows significant value in pharmaceutical applications as it can be used as a pharmaceutical excipient, particularly in the formulation of lipid-based drug delivery systems like lipid nanoparticles (LNPs). By enhancing particle stability through regulating membrane integrity and rigidity, it becomes useful for drug delivery research and development.

Packaging

Avanti Research provides cholesterol (plant derived) in 100mg, 200mg, 500mg, and 1g powder packaging. With over 50 years of experience providing pure lipid products, Avanti Research is thousands of researchers' #1 choice for their lipid research and development.


Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C27H46O
Percent Composition
C 83.87%, H 11.99%, O 4.14%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
57-88-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
386.654
Exact Mass
386.355
Synonyms
cholest-5-en-3ß-ol
110797
730100
Solubility in Different Solvents
Soluble in DMSO at 0.5mg/mL, soluble in ethanol and Chloroform:Methanol (95:5) at 5mg/mL
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References

Singh P, Bodycomb J, Travers B, Tatarkiewicz K, Travers S, Matyas GR, Beck Z. Particle size analyses of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technology. Int J Pharm. 2019 Jul 20;566:680-686. doi: 10.1016/j.ijpharm.2019.06.013. Epub 2019 Jun 6.

 PubMed ID: 31176851

Li H, Liu Q, Crielaard BJ, de Vries JW, Loznik M, Meng Z, Yang X, Göstl R, Herrmann A. Fast, Efficient, and Targeted Liposome Delivery Mediated by DNA Hybridization. Adv Healthc Mater. 2019 May 13:e1900389. doi: 10.1002/adhm.201900389. [Epub ahead of print]

 PubMed ID: 31081288

Wesselhoeft RA, Kowalski PS, Parker-Hale FC, Huang Y, Bisaria N, Anderson DG. RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo. Mol Cell. 2019 Mar 19. pii: S1097-2765(19)30105-4. doi: 10.1016/j.molcel.2019.02.015. [Epub ahead of print]

 PubMed ID: 30902547

Lee SM, Moon JY, Lim BY, Kim SM, Park CW, Kim BJ, Jun JK, Norwitz ER, Choi MH, Park JS. Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia. Sci Rep. 2019 Feb 7;9(1):1550. doi: 10.1038/s41598-018-37757-3.

 PubMed ID: 30733456

Mensch AC, Buchman JT, Haynes CL, Pedersen JA, Hamers RJ. Quaternary Amine-Terminated Quantum Dots Induce Structural Changes to Supported Lipid Bilayers. Langmuir 2018, 34, 12369−12378.

PubMed ID: 30184424

Hasan, I.Y. and A. Mechler. (2016). Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements. Anal Chem [PubMed]

PubMed ID: 27137411

Rajapaksha, M., J. Kaur, M. Bose, R.M. Whittal, and H.S. Bose. (2013). Cholesterol-Mediated Conformational Changes in the Steroidogenic Acute Regulatory Protein Are Essential for Steroidogenesis. Biochemistry Sep 20, 2013 [PubMed]

PubMed ID: 24053410

Hasan, I.Y. and A. Mechler. (2016). Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements. Anal Chem [PubMed]

 PubMed ID: 27137411

Rajapaksha, M., J. Kaur, M. Bose, R.M. Whittal, and H.S. Bose. (2013). Cholesterol-Mediated Conformational Changes in the Steroidogenic Acute Regulatory Protein Are Essential for Steroidogenesis. Biochemistry Sep 20, 2013 [PubMed]

PubMed ID: 24053410

Krause, M.R., S. Turkyilmaz, and S.L. Regen. (2013). Surface Occupancy Plays a Major Role in Cholesterol's Condensing Effect. Langmuir 29:10303-6. [PubMed]

 PubMed ID: 23902525

Kett, P.J., M.T. Casford, and P.B. Davies. (2013). Sum Frequency Generation Vibrational Spectroscopy of Cholesterol in Hybrid Bilayer Membranes. J Phys Chem B [PubMed]

 PubMed ID: 23682921

Pan, J., X. Cheng, F.A. Heberle, B. Mostofian, N. Kucerka, P. Drazba, and J. Katsaras. (2012). Interactions between Ether Phospholipids and Cholesterol As Determined by Scattering and Molecular Dynamics Simulations. J Phys Chem B [PubMed]

PubMed ID: 23199292

Quinn, P.J. (2010) A lipid matrix model of membrane raft structure. Prog Lipid Res. 49:390-406. [PubMed]

 PubMed ID: 20478335

Ziblat, R., I. Fargion, L. Leiserowitz, and L. Addadi. (2012). Spontaneous formation of two-dimensional and three-dimensional cholesterol crystals in single hydrated lipid bilayers. Biophys J 103:255-64. [PubMed]

 PubMed ID: 22853903

Krause, M.R., S. Turkyilmaz, and S.L. Regen. (2013). Surface Occupancy Plays a Major Role in Cholesterol's Condensing Effect. Langmuir 29:10303-6. [PubMed]

PubMed ID: 23902525
Certificates of Analysis

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