700092 | campesterol-d6
campesterol-d6
Campesterol-d6 (chemical structure shown) is a deuterated form of campesterol, which means it is a version of campesterol where some of the hydrogen atoms have been replaced with deuterium, a stable isotope of hydrogen. This labeling with deuterium can be useful in various scientific applications. It is recognized as a biomarker for tracking cholesterol synthesis and absorption.
In application, campesterol-d6 has been utilized as a deuterium-labeled internal standard in gas chromatography (GC), triple quadrupole mass spectrometry and liquid chromatography high-resolution mass spectrometry (LC-HRMS).
Like cholesterol, campesterol is catabolized by intestinal microbes.
This plant sterol is recognized as an analog of cholesterol and a precursor to brassinosteroids (BR) and is synthesized from 24-methylenecholesterol through the enzymatic activity of diminute/dwarf1. Campesterol possesses methyl group at the C-24 position of the side chain in the cholesterol structure.
Campesterol-d6 Applications
One notable application involves its use as a plant sterol to assess its impact on the transcriptional activation of liver X receptor ɑ(LXRA) in breast cancer cells. It also serves as a valuable sterol standard for creating calibration curves in liquid chromatography multiple reaction monitoring (LC-MRM) analysis.
Additionally, the versatility of campesterol-d6 is highlighted by the fact that it does possess chemopreventive functionality in prostate and breast tumors, showcasing its potential in cancer research use and preventive medicine. Moreover, its antiangiogenic property suggests a promising avenue for treating disorders related to abnormal angiogenesis.
Plant sterols like campesterol-d6 are derived primarily from nuts, fruits, legumes, and seeds, campesterol is a unique phytosterol property. Despite its analog status to cholesterol, it exhibits poor absorption in humans and competes effectively to inhibit cholesterol absorption. The beneficial effects of campesterol extend to the reduction of chylomicron, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL)-apoB100 levels.
Purchase campesterol-d6 in its powder form from the most reputable lipid supplier, Avanti Research, in 1mg packaging.
CAS Registry Number is a Registered Trademark of the American Chemical Society
111018
Powered by BiozWu AH, Ruan W, Todd J, Lynch KL. Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin Chim Acta. 2014 Mar 20;430:43-7. doi: 10.1016/j.cca.2013.12.040. Epub 2014 Jan 4. PMID: 24394292.
PubMed ID: 24394292- Certificate of Analysis (Lot No. 700092P-1MG-A-010 and 5174PGA010)
- Certificate of Analysis (Lot No. 700092P-1MG-B-010 and 5174PGB010)
- Certificate of Analysis (Lot No. 700092P-1MG-C-010 and 5174PGC010)
- Certificate of Analysis (Lot No. 700092P-1MG-D-010 and 5174PGD010)
