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700017 | 25-hydroxycholesterol-3-sulfate

25-hydroxycholesterol-3-sulfate (sodium salt)

25-hydroxycholesterol-3-sulfate

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5mg 700017P-5mg 700017P-5mg 1 x 5mg $412.35
10mg 700017P-10mg 700017P-10mg 1 x 10mg $617.20
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Info

25-hydroxycholesterol-3-sulfate

25-hydroxycholesterol-3-sulfate (sodium salt)

Product Overview:
25-hydroxycholesterol-3-sulfate is a synthetic sulfated oxysterol. It consists of an oxysterol backbone and a sulfated head group. Oxysterol sulfates, such as 25-hydroxycholesterol 3-sulfate, are emerging as key players in lipid homeostasis, inflammation and immunity. 

https://doi.org/10.1038/s41419...

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C27H45NaO5S
Percent Composition
C 64.25%, H 8.99%, Na 4.56%, O 15.85%, S 6.35%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
884905-07-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
504.698
Exact Mass
504.289
Synonyms
5-cholesten-3beta, 25-diol 3-sulfate
25HC3S
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References

Beck KR, Inderbinen SG, Kanagaratnam S, Kratschmar DV, Jetten AM, Yamaguchi H, Odermatt A. 11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ. J Lipid Res. 2019 Sep;60(9):1535-1546. doi: 10.1194/jlr.M092908. Epub 2019 Jul 4. PMID: 31273032; PMCID: PMC6718442.

 PubMed ID: 31273032

Xu L, Bai Q, Rodriguez-Agudo D, Hylemon PB, Heuman DM, Pandak WM, Ren S. Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate. Lipids. 2010 Sep;45(9):821-32. doi: 10.1007/s11745-010-3451-y. Epub 2010 Aug 11. PMID: 20700770.

 PubMed ID: 20700770

Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, Ren S. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1369-79. doi: 10.1152/ajpendo.90555.2008. Epub 2008 Oct 14. PMID: 18854425; PMCID: PMC2603552.

 PubMed ID: 18854425

Ren S, Li X, Rodriguez-Agudo D, Gil G, Hylemon P, Pandak WM. Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun. 2007 Sep 7;360(4):802-8. doi: 10.1016/j.bbrc.2007.06.143. Epub 2007 Jul 6. PMID: 17624300; PMCID: PMC2728003.

 PubMed ID: 17624300
Solubility

Soluble in 50% ethanol at ~1mg/mL.

Certificates of Analysis

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