699857 | FP-20, sodium salt
sodium (2R,3S,4R,5R,6S)-5-dodecanamido-4,6-bis(dodecanoyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl phosphate
Please Confirm Your Location
Effective March 1, 2018, Merck KGaA, Darmstadt, Germany* is the exclusive Distributor of Avanti Research. Research Products for all countries except the United States. For product pricing and order placement, please click on the appropriate Location Box below.
For customers located outside the United States, you will be redirected to www.sigmaaldrich.com/avanti prior to completing your purchase. Thank you for your continued business and support of Avanti Research!
*The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada
FP-20, sodium salt
sodium (2R,3S,4R,5R,6S)-5-dodecanamido-4,6-bis(dodecanoyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl phosphate
Sodium (2R,3S,4R,5R,6S)-5-dodecanamido-4,6-bis(dodecanoyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl phosphate, or FP-20, sodium salt is a synthetic adjuvant and toll-like receptor 4 (TLR4) agonist designed to improve immune responses in vaccine formulations. It features a glucosamine monosaccharide core with three C12 fatty acid chains and a phosphate group.
FP-20, sodium salt is engineered to stimulate innate immunity that leads to robust adaptive immune activation. FP-20’s potent immunostimulatory properties make it a promising candidate for next-generation vaccine adjuvant systems.
Application
Research involving FP-20 shows potential for increasing vaccine efficacy by improving cancer immunotherapy and improving the immune system’s response to tumor-associated antigens.
Additionally, researchers are exploring FP-20’s role in vaccines that target infectious diseases, including the flu, HIV, and tuberculosis. Its powerful ability to trigger strong immune responses shows potential for improving vaccine effectiveness across various pathogens.
Another notable characteristic of FP-20 is its ability to be used alongside other adjuvants, such as QS-21, to create immune-enhancing effects and boost vaccine performance further.
Packaging
Avanti Research™ provides FP-20, sodium salt in powder (5mg and 10mg) for targeted research in cancer, infectious diseases, and more.
Our 50+ years of experience are here to put your research a step ahead.
C42H79NNaO11P
C 60.92%, H 9.25%, H 1.69%, Na 2.78%, O 21.25%, P 3.74%
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozJ. Med. Chem. 2023, 66, 4, 3010–3029Publication Date:February 2, 2023https://doi.org/10.1021/acs.jmedchem.2c01998
ACS Omega 2023, 8, 39, 36412–36417Publication Date:September 18, 2023https://doi.org/10.1021/acsomega.3c05363
J. Med. Chem. 2021, 64, 16, 12261–12272Publication Date:August 12, 2021https://doi.org/10.1021/acs.jmedchem.1c00896
- Certificate of Analysis (Lot No. 699857P-5MG-A-010 and 7275PHA010)
- Certificate of Analysis (Lot No. 699857P-10MG-A-010 and 7275PIA010)
