699857 | FP-20, sodium salt
sodium (2R,3S,4R,5R,6S)-5-dodecanamido-4,6-bis(dodecanoyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl phosphate
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FP-20, sodium salt
sodium (2R,3S,4R,5R,6S)-5-dodecanamido-4,6-bis(dodecanoyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl phosphate
FP-20 sodium salt is a synthetic adjuvant and toll-like receptor 4 (TLR4) agonist designed to improve immune responses in vaccine formulations. It features a glucosamine monosaccharide core with three C12 fatty acid chains and a phosphate group.
A 2024 Journal of Medicinal Chemistry study (ACS J. Med. Chem. 2024, 67, 8, 5678–5692) reports its phase-transition temperature (Tₘ) is 43.9 °C, highlighting its favorable thermal stability for vaccine formulation and storage.
Application
By engaging both MyD88- and TRIF-dependent TLR4 pathways, FP-20 sodium salt induces robust cytokine secretion, including TNF-α, IL-6, IL-1β, and Type I interferons, according to a 2023 Journal of Medicinal Chemistry study (Romerio et al., ACS J. Med. Chem. 2023, 66, 4, 3010–3029). These responses make it especially valuable for oncology and infectious disease vaccine research. Preclinical models suggest strong utility in amplifying immunity against tumor-associated antigens and pathogens such as influenza, HIV, and Mycobacterium tuberculosis.
Another notable characteristic of FP-20 sodium salt is its ability to be used alongside other adjuvants, such as QS-21, to create immune-enhancing effects and further boost vaccine performance.
Packaging
Avanti Research™ provides FP-20 sodium salt in 5mg and 10mg powder packaging for targeted research in cancer, infectious diseases, and more.
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C42H79NNaO11P
C 60.92%, H 9.25%, H 1.69%, Na 2.78%, O 21.25%, P 3.74%
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozJ. Med. Chem. 2023, 66, 4, 3010–3029Publication Date:February 2, 2023https://doi.org/10.1021/acs.jmedchem.2c01998
ACS Omega 2023, 8, 39, 36412–36417Publication Date:September 18, 2023https://doi.org/10.1021/acsomega.3c05363
J. Med. Chem. 2021, 64, 16, 12261–12272Publication Date:August 12, 2021https://doi.org/10.1021/acs.jmedchem.1c00896
- Certificate of Analysis (Lot No. 699857P-5MG-A-010 and 7275PHA010)
- Certificate of Analysis (Lot No. 699857P-10MG-A-010 and 7275PIA010)
