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699810 | PHAD™-504

Monophosphoryl Lipid A-504

PHAD™-504

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Size SKU Packaging Price
1mg 699810P-1mg 699810P-1mg $283.13
5mg 699810P-5mg 699810P-5mg $1,132.55
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PHAD™-504

Monophosphoryl Lipid A-504

PHAD™-504 was designed as a synthetic structural analog of detoxified MPLA derived from E. coli lipopolysaccharide (LPS). It is structurally similar to PHAD™, differing only in the length of a single fatty acid chain. As expected, the activity of PHAD™-504 is quite similar to that of PHAD™, making the two products interchangeable as adjuvants in vaccine or immunotherapy formulations.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C94H180 N3O22P
Percent Composition
C 65.06% H 10.45% N 2.42% O 20.28% P 1.78 %
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
Formula Weight
1735.42
Exact Mass
1734.28
Solubility in Different Solvents
The solubility in ethanol (as well as other alcohols) and DMSO is limited. Additionally, this species is insoluble in water (aqueous buffers, serum etc.); however, it can be dispersed in an aqueous medium using a suitable emulsifier or detergent. This species is soluble in chloroform (at least up to 50 mg/mL) and chloroform:methanol solvent systems, however gentle heating and sonication may be necessary to aid in dissolution. Dropwise additions of methanol or water may aid dissolution in chloroform at higher concentrations. If using in combination with other lipids, dissolve this lipid separately and then combine dissolved lipids in their respective solvent solutions.
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References

Ji Y, An J, Hwang D, Ha DH, Lim SM, Lee C, Zhao J, Song HK, Yang EG, Zhou P, Chung HS. Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant. Metab Eng. 2020 Jan;57:193-202. doi: 10.1016/j.ymben.2019.11.009. Epub 2019 Nov 28. PMID: 31786244; PMCID: PMC6960009.

 PubMed ID: 31786244
Certificates of Analysis

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