699810 | PHAD™-504
Monophosphoryl Lipid A-504
Info
PHAD™-504
Monophosphoryl Lipid A-504
PHAD™-504 was designed as a synthetic structural analog of detoxified MPLA derived from E. coli lipopolysaccharide (LPS). It is structurally similar to PHAD™, differing only in the length of a single fatty acid chain. As expected, the activity of PHAD™-504 is quite similar to that of PHAD™, making the two products interchangeable as adjuvants in vaccine or immunotherapy formulations.
Data
No
No
C94H180 N3O22P
C 65.06% H 10.45% N 2.42% O 20.28% P 1.78 %
>99%
1 year
-20°C
1735.42
1734.28
The solubility in ethanol (as well as other alcohols) and DMSO is limited. Additionally, this species is insoluble in water (aqueous buffers, serum etc.); however, it can be dispersed in an aqueous medium using a suitable emulsifier or detergent. This species is soluble in chloroform (at least up to 50 mg/mL) and chloroform:methanol solvent systems, however gentle heating and sonication may be necessary to aid in dissolution. Dropwise additions of methanol or water may aid dissolution in chloroform at higher concentrations. If using in combination with other lipids, dissolve this lipid separately and then combine dissolved lipids in their respective solvent solutions.
References
Ji Y, An J, Hwang D, Ha DH, Lim SM, Lee C, Zhao J, Song HK, Yang EG, Zhou P, Chung HS. Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant. Metab Eng. 2020 Jan;57:193-202. doi: 10.1016/j.ymben.2019.11.009. Epub 2019 Nov 28. PMID: 31786244; PMCID: PMC6960009.
PubMed ID: 31786244
Certificates of Analysis
- Certificate of Analysis (Lot No. 699810P-1MG-A-010 and 5087PGA010)
- Certificate of Analysis (Lot No. 699810P-5MG-A-010 and 5087PHA010)
- Certificate of Analysis (Lot No. 699810P-1MG-B-010 and 5087PGB010)
- Certificate of Analysis (Lot No. 699810P-5MG-B-010 and 5087PHB010)
- Certificate of Analysis (Lot No. 699810P-5MG-C-010 and 5087PHC010)
- Certificate of Analysis (Lot No. 699810P-1MG-C-010 and 5087PGC010)
- Certificate of Analysis (Lot No. 699810P-5MG-D-010 and 5087PHD010)
- Certificate of Analysis (Lot No. 699810P-1MG-E-010 and 5087PGE010)