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640010 | DMABA-d10 NHS Ester

4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic-2,3,5,6-d4 acid

DMABA-d10 NHS Ester

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DMABA-d10 NHS Ester

4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic-2,3,5,6-d4 acid

The DMABA NHS ester reagents were developed by Dr. Robert Murphy’s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
d4-DMABA Derivatived Brain PE Extract. A. The positive ion electrospray mass spectrum of brain PE lipid extract. B. The NL141 scan of brain PE lipid extract. C. The positive ion electrospray mass spectrum of d4-DMABA derivatized brain PE lipid extract, which is shifted in mass +151 amu when compared with the spectrum of unlabeled brain PE extract. D. P195 amu to selectively detect the d4-DMABA labeled species in the brain PE extract.
Fragmentation of DMABA NHS Ester Reagents. (Described by Berry, et al.)
Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C13H4D10N2O4
Percent Composition
C 57.34%, H 8.88%, N 10.29%, O 23.50%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1175002-05-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
272.323
Exact Mass
272.158
Synonyms
4-(dimethylamino)benzoic acid
N-hydroxysuccinimide ester-d10
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References

Zemski Berry KA, Turner WW, VanNieuwenhze MS, Murphy RC. Stable isotope labeled 4-(dimethylamino)benzoic acid derivatives of glycerophosphoethanolamine lipids. Anal Chem. 2009 Aug 15;81(16):6633-40. doi: 10.1021/ac900583a. PMID: 20337376; PMCID: PMC2929906.

 PubMed ID: 20337376

Zemski Berry KA, Turner WW, VanNieuwenhze MS, Murphy RC. Characterization of oxidized phosphatidylethanolamine derived from RAW 264.7 cells using 4-(dimethylamino)benzoic acid derivatives. Eur J Mass Spectrom (Chichester). 2010;16(3):463-70. doi: 10.1255/ejms.1083. PMID: 20530831; PMCID: PMC3086548.

 PubMed ID: 20530831

Fruhwirth GO, Loidl A, Hermetter A. Oxidized phospholipids: from molecular properties to disease. Biochim Biophys Acta. 2007 Jul;1772(7):718-36. doi: 10.1016/j.bbadis.2007.04.009. Epub 2007 May 6. PMID: 17570293.

 PubMed ID: 17570293

Grimm MO, Haupenthal VJ, Rothhaar TL, Zimmer VC, Grösgen S, Hundsdörfer B, Lehmann J, Grimm HS, Hartmann T. Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease. Int J Mol Sci. 2013 Mar 13;14(3):5879-98. doi: 10.3390/ijms14035879. PMID: 23485990; PMCID: PMC3634454.

 PubMed ID: 23485990

Kosicek M, Hecimovic S. Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers. Int J Mol Sci. 2013 Jan 10;14(1):1310-22. doi: 10.3390/ijms14011310. PMID: 23306153; PMCID: PMC3565322.

 PubMed ID: 23306153

Ueda Y, Kawakami Y, Kunii D, Okada H, Azuma M, Le DS, Yamamoto S. Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. Nutr Res. 2008 Apr;28(4):239-44. doi: 10.1016/j.nutres.2008.02.005. PMID: 19083414.

 PubMed ID: 19083414
Certificates of Analysis

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