330280 | Taurolithocholic acid-d4, sodium salt
5ß-cholanic acid-3a-ol N-(2-sulphoethyl)-amide-d4, sodium salt
Taurolithocholic acid-d4, sodium salt
5ß-cholanic acid-3a-ol N-(2-sulphoethyl)-amide-d4, sodium salt
Taurolithocholic Acid-d4 is a deuterated variation compound of the bile acid (BA) conjugate taurolithoholic acid. As a deuterated form, Taurolithocholic Acid-d4 contains atoms of deuterium - a stable hydrogen isotope, instead of hydrogen atoms.
Taurolithocholic acid (Taurolithocholate/Lithocholyltaurine) is a human metabolite found predominantly in human bile, usually as sodium salt. It’s derived in the liver hepatocytes from the conjugation of the secondary BA lithocholic acid with the amino acid taurine. Its precursor, lithocholic acid is produced from one of the primary BAs - chenodeoxycholic acid, by a process of reduction of the hydroxyl functional group at C-7 position. Lithocholic acid is known as a detergent that’s involved in animal and human neoplasm development and progression.
Its derivative, taurolithocholic acid, is found to solubilize fats and other sterols for absorption and is itself absorbed. It’s also a cholagogue and a coleretic agent.
Experimental analyses have shown that the taurine conjugate increases caspase-3 and caspase-7, apoptosis molecules, in Hep3B cells - a cell line that contains an integrated hepatitis B virus genome.
It’s also proven that serum concentrations of taurolithocholic acid get elevated within two hours during an oral lipid tolerance test in human organisms.
The isotope form of taurolithocholic acid, Taurolithocholic Acid-d4 is intended for use as an internal standard for the quantification of taurolithocholic acid.
Produced by a team of expert scientists and modern research equipment, Avanti’s Taurolithocholic Acid-d4 is a pure and quality bile acid to include in your experimental projects.
C26H40D4NNaO5S
C 61.27%, H 9.49%, N 2.75%, Na 4.51%, O 15.69%. S 6.29%
CAS Registry Number is a Registered Trademark of the American Chemical Society
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