330278 | Taurocholic acid-d4, sodium salt
5β-cholanic acid-3α,7α,12α-triol N-(2-sulphoethyl)-amide-d4, sodium salt
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Taurocholic acid-d4, sodium salt
5β-cholanic acid-3α,7α,12α-triol N-(2-sulphoethyl)-amide-d4, sodium salt
Taurocholic Acid is a human metabolite and a byproduct of the primary bile acid (BA) cholic acid, obtained from its conjugation with the nonessential amino acid taurine.
The compound is also a derivative of taurocholic acid, another taurine conjugate of cholic acid, found in the bile of mammals.
Bile acids are amphipathic steroid molecules, synthesized in the liver from precursor cholesterol. Their main role in the human body is to act as detergents that solubilize fats and sterols, including other BAs and hydrophobic nutrients, for absorption and transport. Bile acids also balance bile flow and modulate its secretion.
Over the past few years, these compounds are strongly believed to be involved as signaling molecules in the regulation of cholesterol and glucose homeostasis, energy expenditure, pathological pathways such as inflammation, and more. BAs flow through intrahepatic ducts and the intestines, then are reabsorbed via enterohepatic circulation and further metabolized in the liver, which additionally increases their chemical diversity. BAs own some cytotoxic abilities, as well.
Apart from these properties, taurocholic acid has some more features, that premise specific uses and applications of the compound and its derivatives, including Taurocholic Acid-D4, and sodium salt.
Taurocholic Acid-D4 levels are found to decrease in patients with Crohn’s disease and ulcerative colitis without extraintestinal manifestations, whereas in patients with ulcerative colitis with complications like hepatobiliary disease, the taurine conjugate increases.
Taurocholic Acid-D4 is meant for use as an internal standard for the quantification of taurocholic acid. This analysis involves mass spectrometry to study gut bacteria in relation to metabolic disorders.
The derivative is suitable to investigate taurocholic acid and other BAs regarding a range of biological pathways and processes.
Avanti’s Taurocholic Acid-D4, sodium salt bile acid is guaranteed to meet the highest specifications for purity, stability, and quality.
C26H40D4NNaO7S
C 57.65%, H 8.93%, N 2.59%, Na 4.24%, O 20.67%, S 5.92%
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by Bioz- Certificate of Analysis (Lot No. 330278P-1MG-A-010 and 6908PGA010)
- Certificate of Analysis (Lot No. 330278P-1MG-B-010 and 6908PGB010)
- Certificate of Analysis (Lot No. 330278P-1MG-C-010 and 6908PGC010)
