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Isotope Labeled


The success of the lipidomics field has led to an increased interest in deuterium-labeled lipids. Deuterated glycosphingolipids are commonly used tools to help elucidate structures of naturally occurring glycosphingolipids via mass spec and NMR. Deuterated glycosphingolipids are also used in various NMR studies and have been used to determine which glycosphingolipids are present in biological samples. Not only can deuterated glycosphingolipids be used for structure elucidation and identification, they can be used to better understand glycosphingolipid dynamics and function within cells and cell membranes.

These cellular functions differ when comparing gangliosides to globosides. Gangliosides play a key role in organization and stability of membrane structures, cell signaling, recognition processes, and neuronal development. Globosides are also key players in membrane stability, cell adhesion, and recognition events, but they also play a role in intracellular signaling pathways which influences cellular responses to external stimuli.

Reference: Gyamfi, D., Ofori Awuah, E., & Owusu, S. (2018). Chapter 2 - Lipid Metabolism: An Overview. The Molecular Nutrition of Fats, 17–32. https://doi.org/https://doi.or...