Coenzyme A & Derivatives
Coenzyme A (CoA) is a derivative of vitamin B5 and cysteine. One of CoA’s largest roles comes in the form of acetyl-CoA. Acetyl-CoA is produced when CoA is linked to an acetyl group through a thioester bond. Acetyl-CoA plays a key role in intermediate metabolism in organisms ranging from archaebacteria to mammals. Some of its major roles include being a precursor of anabolic reactions, regulation of enzymatic activity via allosteric interactions, and facilitation of acetyl transfer to proteins. Acetyltransferases (NATs) facilitate the transfer of an acetyl group from acetyl-CoA to the "-amino group on the N-terminal residue of a protein. This terminal acetylation greatly affects the stability and function of a protein. The abundance of acetyl-CoA in cellular compartments can change based on various physiological and/or pathological conditions. Research has shown that acetyl-CoA is involved in some cell regulation processes via its ability to control the balance between anabolic and catabolic reactions. Several pharmaceutical agents have been and continue to be developed to influence acetyl-CoA metabolism.
Choudhary C., Weinert B.T., Nishida Y., Verdin E., Mann M. The growing landscape of lysine acetylation links metabolism and cell signaling. Nat. Rev. Mol. Cell Biol. 2014; 15: 536-550
Lundby A., Lage K., Weinert B.T., Bekker-Jensen D.B., Secher A., Skovgaard T., Kelstrup C.D., Dmytriyev A., Choudhary C., Lundby C., Olsen J.V. Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep. 2012; 2: 419-431
Pietrocola, F., Galluzzi, L., Bravo-San Pedro, J.M., Madeo, F., Kroemer, G. Acetyl Coenzyme A: A Central Metabolite and Second Messenger. Cell Metabolism. 2015; 21: 805-821
- Coenzyme A
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Acyl CoA - Saturated Fatty Acid
- BUY 870702 - 02:0 Coenzyme A
- BUY 870703 - 03:0 Coenzyme A
- BUY 870704 - 04:0 Coenzyme A
- BUY 870706 - 06:0 Coenzyme A
- BUY 870708 - 08:0 Coenzyme A
- BUY 870710 - 10:0 Coenzyme A
- BUY 870712 - 12:0 Coenzyme A
- BUY 870713 - 13:0 Coenzyme A
- BUY 870714 - 14:0 Coenzyme A
- BUY 870715 - 15:0 Coenzyme A
- BUY 870716 - 16:0 Coenzyme A
- BUY 870717 - 17:0 Coenzyme A
- BUY 870718 - 18:0 Coenzyme A
- BUY 870720 - 20:0 Coenzyme A
- BUY 870722 - 22:0 Coenzyme A
- BUY 870723 - 23:0 Coenzyme A
- BUY 870724 - 24:0 Coenzyme A
- BUY 870726 - 26:0 Coenzyme A
- BUY 870727 - 28:0 Coenzyme A
- BUY 870729 - 25:0 Coenzyme A
- BUY 870734 - 18:0(α-OH) Coenzyme A
- BUY 870735 - 14:0 Ether Coenzyme A
- BUY 870738 - 19:0 Coenzyme A
- BUY 870739 - 21:0 Coenzyme A
- BUY 870740 - 16:0 Ether Coenzyme A
- BUY 870745 - 30:0 Coenzyme A
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Acyl CoA - Unsaturated Fatty Acid
- BUY 870709 - 04:1 Coenzyme A
- BUY 870719 - 18:1 (n9) Coenzyme A
- BUY 870721 - 20:4 Coenzyme A
- BUY 870725 - 24:1 Coenzyme A
- BUY 870728 - 22:6 Coenzyme A
- BUY 870730 - 18:1(n7) Coenzyme A
- BUY 870731 - 18:1 (n12) Coenzyme A
- BUY 870732 - 18:3 (n3) Coenzyme A
- BUY 870733 - 18:3 (n6) Coenzyme A
- BUY 870736 - 18:2 (n6) Coenzyme A
- BUY 870737 - 17:1 (n7) Coenzyme A
- BUY 870741 - 18:1 Ether Coenzyme A
- BUY 870743 - 16:1 (n7) Coenzyme A
- BUY 870744 - 20:5 Coenzyme A
- Derivatives