Inhibitors of Sphingolipid Metabolism
Sphingolipids are able to exert cell signaling effects. Ceramide is a central component of sphingolipid metabolism that is tightly regulated due to its pro-apoptotic effect. Enzymes involved in the conversion of ceramide to other sphingolipids have been targeted in drug resistance by depleting ceramide to produce pro-survival sphingolipids. Sphingosine kinases, ceramidase, glucosylceramide synthase, and ceramide synthase are all enzymes involved in the metabolism of sphingolipids. Check out Avanti’s wide variety of sphingolipid metabolism inhibitors below!
Lewis, A.C., Wallington-Beddoe, C.T., Powell, J.A., et al. Targeting sphingolipid metabolism as an approach for combination therapies in hematological malignancies. Cell Death Discov. 4, 72 (2018). https://doi.org/10.1038/s41420-018-0075-0
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- BUY 857392 - (R)-FTY720-OMe
- BUY 857393 - THI
- BUY 857395 - GT-11
- BUY 860455 - N-C12-deoxysphingosine
- BUY 860456 - N-C16-deoxysphingosine
- BUY 860457 - N-C24:1-deoxysphingosine
- BUY 860461 - N-C12-desoxymethylsphinganine
- BUY 860462 - N-C16-deoxysphinganine
- BUY 860463 - N-C16-desoxymethylsphinganine
- BUY 860464 - N-C24:1-deoxysphinganine
- BUY 860465 - N-C24:1-desoxymethylsphinganine
- BUY 860466 - N-C12-desoxymethylsphingosine
- BUY 860467 - N-C16-desoxymethylsphingosine
- BUY 860468 - N-C24:1-desoxymethylsphingosine
- BUY 860470 - 1-deoxysphingosine
- BUY 860473 - 1-desoxymethylsphinganine
- BUY 860477 - 1-desoxymethylsphingosine
- BUY 860479 - Adamantanyl Galactosyl(ß) Ceramide
- BUY 860480 - C10 bisphosphonate
- BUY 860488 - Safingol
- BUY 860493 - 1-deoxysphinganine
- BUY 860771 - Enigmol(2S,3S,5S)
- BUY 860772 - N-C6-Enigmol(2S,3S,5S)
- BUY 870792 - D-threo-PPMP