Avanti Research’s comprehensive approach to lipid solutions for drug delivery

Let’s explore Avanti Research’s comprehensive approach to lipid solutions for drug delivery, highlighting our product offerings, focus on innovation, and commitment to quality! As a leading provider of lipid solutions for lipid nanoparticle (LNP) delivery systems, Avanti Research supports the encapsulation and transport of therapeutic agents, such as mRNA and siRNA, directly to target cells within the body.

We offer a wide range of lipids designed for specific applications in drug delivery, including:

• Functionalized PEG Lipids: These lipids are conjugated with polyethylene glycol (PEG) and can be further modified for targeted delivery. They allow linking to molecules like antibodies, proteins, peptides, folate, and triGalNac, facilitating receptor-mediated uptake by specific cells.
• Polysarcosine Lipids: We present these lipids as a potential alternative to PEGylated lipids. They offer stealth properties, potentially reducing immunogenicity and enhancing mRNA transfection efficiency. Available in various forms, these lipids feature tunable chain lengths and saturated or unsaturated structures. Saturated lipids help achieve longer circulation times and stability, while unsaturated lipids improve particle uptake across a range of cell lines.
• Structural Lipids: Selecting the right structural lipids is essential for effective LNP performance. Avanti provides options like DSPC and DOPC, known for their stability-enhancing properties. We emphasize the unique roles of different lipid headgroups, such as phosphatidylethanolamine (PE), which promotes a hexagonal structure that enhances intracellular delivery of nucleic acids, and sphingomyelin, which can improve transfection in both hepatic and extrahepatic tissues.
• Cationic Lipids: Available in fixed and ionizable forms, cationic lipids are crucial for complexing with negatively charged nucleic acids. Avanti offers a range of cationic lipids, including DOTAP, DDAB, DOTMA, DODMA, and DOSPA, with varied fatty acid chains and saturations that optimize their interaction with nucleic acids and cellular uptake.
• Cholesterol Substitutes: We provide alternatives to cholesterol, such as sitosterol and delta-5-avenasterol, which can enhance mRNA transfection and are particularly effective for non-injectable delivery routes like inhalation.

At Avanti, we recognize the "PEG dilemma" and the potential immunogenicity concerns associated with PEGylated lipids. As a potential solution, we offer polysarcosine lipids, which may present a lower immunogenicity risk.

In addition to our diverse lipid portfolio, Avanti is deeply committed to quality and regulatory compliance throughout the product life cycle. Our analytical laboratory in Alabaster, Alabama, conducts over 20,000 routine analyses annually, develops new analytical methods, and oversees the release of more than 800 raw materials and 1,200 product batches. Avanti complies with FDA regulations and ICH guidelines, performing rigorous quality control measures to ensure our products’ quality and purity. We offer analytical support throughout the drug development process, from early research stages to commercial manufacturing.

At Avanti Research, our commitment to advancing drug delivery systems extends to our specialized Nucleic Acid Delivery Platform, a comprehensive resource designed to support customers through every phase of developing and optimizing nucleic acid therapies. This platform provides a variety of tailored solutions that facilitate the efficient and stable delivery of nucleic acids, including mRNA, siRNA, and DNA, ensuring they reach their target cells within the body.

With an understanding of the unique challenges associated with nucleic acid delivery, Avanti offers an extensive portfolio of LNP-compatible lipids and expert guidance to help customers achieve optimal encapsulation, stability, and efficacy for their therapeutic agents. From selecting the right lipids for specific applications to providing analytical support and regulatory guidance, our platform is engineered to streamline the journey from research to clinical application. With Avanti’s nucleic acid delivery expertise, we empower our customers to accelerate breakthroughs in gene therapy, vaccines, and other transformative treatments.

From research innovation to GMP excellence, we're with you every step of the way!